Gold-catalyzed intermolecular cyclocarboamination of ynamides with 1,3,5-triazinanes: en route to tetrahydropyrimidines was written by Zeng, Zhongyi;Jin, Hongming;Song, Xinlong;Wang, Qian;Rudolph, Matthias;Rominger, Frank;Hashmi, A. Stephen K.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.Computed Properties of C11H9NO2 This article mentions the following:
Gold-catalyzed regioselective cyclocarboamination of ynamides R1CCR2 [R1 = 4-methoxyphenyl, 3-chlorophenyl, 6-methoxynaphth-2-yl, etc. R2 = methyl(2,4,6-trimethylphenyl)aminyl, 2-oxo-1,3-oxazolidin-3-yl, 3-acetyl-1H-indol-1-yl, etc.] with 1,3,5-triazinanes I (Ar = Ph, 2-fluorophenyl, 3-methyl-4-chlorophenyl, etc.) opens a facile and modular access to valuable 5-aminotetrahydropyrimidines II in good to excellent yields. The aminotetrahydropyrimidines constitutes an unprecedented yet challenging annulation of ynamides with unstrained saturated heterocycles. This new protocol is distinguished by easy operation, readily available starting materials, stable four-atom building units, good functional-group compatibility and scaling-up potential. The preliminary mechanistic studies indicate that the present intermol. cyclocarboamination arises from a pseudo-three-component [2+2+2] cycloaddition In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Computed Properties of C11H9NO2).
3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Computed Properties of C11H9NO2
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem