Asymmetric synthesis of non-natural amino acid derivatives: (2R/3S) and (2S/3R) 2-(tert-butoxycarbonylamino)-3-cyclohexyl-3-phenyl propanoic acids was written by Yang, Rui;Guo, Ya-Fei;Gao, Zhan-Yong;Zhao, Qian;Zhang, Qian-Yang;Lin, Jun. And the article was included in Journal of Chemical Research in 2015.Recommanded Product: 99395-88-7 This article mentions the following:
Highly conformationally-constrained novel α-amino acid derivatives ((2R/3S) and (2S/3R)-2-(Boc-amino)-3-cyclohexyl-3-phenylpropanoic acids) (Boc = tert-butoxycarbonyl) have been synthesized with high stereoselectivity (> 90% de) and in 36-37% overall yields. In the synthesis, Evans’ auxiliary (4(R/S)-4-phenyl-oxazolidin-2-one) was used to control the stereoselectivity via the key reactions of asym. Michael addition, azidation and catalytic hydrogenolysis. In the experiment, the researchers used many compounds, for example, (S)-4-Phenyloxazolidin-2-one (cas: 99395-88-7Recommanded Product: 99395-88-7).
(S)-4-Phenyloxazolidin-2-one (cas: 99395-88-7) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Recommanded Product: 99395-88-7
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem