Metal-free intermolecular formal cycloadditions enable an orthogonal access to nitrogen heterocycles was written by Xie, Lan-Gui;Niyomchon, Supaporn;Mota, Antonio J.;Gonzalez, Leticia;Maulide, Nuno. And the article was included in Nature Communications in 2016.COA of Formula: C11H9NO2 This article mentions the following:
A family of metal-free intermol. formal cycloaddition reactions that enable highly selective and orthogonal access to isoquinolines, e.g., I and pyrimidines II (R = CH3, 4-FC6H4, H2CC6H5, etc.; R1 = CH3, 4-FC6H4, cyclohexyl, etc.; R2 = heptyl, cyclopropyl, 4-chlorophenyl, etc.; R3 = SMe, 2-oxo-1,3-oxazolidin-3-yl) has been described. Applications of the products are complemented by a d. functional theory mechanistic anal. that pinpoints the crucial factors responsible for the selectivity observed, including stoichiometry and the nature of the heteroalkyne. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2COA of Formula: C11H9NO2).
3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.COA of Formula: C11H9NO2
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem