The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Synthesis, molecular modeling and biological activity of methyl and thiomethyl substituted pyrimidines as corticotropin releasing hormone type 1 antagonists, the main research direction is methyl thiomethyl substituted pyrimidine preparation mol modeling biol activity; corticotropin releasing hormone antagonist methyl thiomethyl substituted pyrimidine.Formula: C5H6N2O2.
Four small, targeted libraries of differentially substituted amino pyrimidines were synthesized in moderate to good yields. Excellent regiochem. was observed for substitution at C2/C4 with selectivity >50 : 1 noted. All analogs were screened for their ability to interact with CRH1 and CRH2 receptors. In all instances only poor agonistic and/or antagonistic behavior was noted at CRH2. However, several compounds were potent and selective CRH1 antagonists, most notably one compound showed Ki = 39 nM. Addnl. we have utilized these data and that recently reported by others to refine our original CRH1 pharmacophore (J. Med. Chem., 1999, 42, 2351-2357).
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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem