Synthesis of δ- and α-carbolines via nickel-catalyzed [2+2+2] cycloaddition of functionalized alkyne-nitriles with alkynes was written by Wang, Gaonan;You, Xu;Gan, Yi;Liu, Yuanhong. And the article was included in Organic Letters in 2017.Related Products of 888329-88-2 This article mentions the following:
A new method for the synthesis of δ- and α-carbolines I, II, resp., through Ni-catalyzed [2+2+2] cycloaddition of ynamide-nitriles 2-R1CCNTsC6H4CN (1) or alkyne-cyanamides 2-(R1CC)C6H4N(Ts)CN (3) with alkynes R2CCR3 has been developed. The catalytic system of NiCl2(DME)/dppp/Zn with a low-cost Ni(II)-precursor was first utilized in Ni-catalyzed [2+2+2] cycloaddition reactions, and the in situ generated Lewis acid may play an important role for the successful transformation. Not only internal alkynes but also terminal alkynes undergo the desired cycloaddition reactions efficiently to furnish the carboline derivatives with wide diversity and functional group tolerance. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Related Products of 888329-88-2).
3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Related Products of 888329-88-2
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem