Synthesis of Chiral 5-Aryl-2-oxazolidinones via Halohydrin Dehalogenase-Catalyzed Enantio- and Regioselective Ring-Opening of Styrene Oxides was written by Wan, Nanwei;Zhou, Xiaoying;Ma, Ran;Tian, Jiawei;Wang, Huihui;Cui, Baodong;Han, Wenyong;Chen, Yongzheng. And the article was included in Advanced Synthesis & Catalysis in 2020.Recommanded Product: (S)-4-Phenyloxazolidin-2-one This article mentions the following:
An efficient biocatalytic approach for enantio- and regioselective ring-opening of styrene oxides I (R = H, 3-Cl, 4-Me, 4-Br, etc.) with sodium cyanate was developed by using the halohydrin dehalogenase HheC from Agrobacterium radiobacter AD1, generating the corresponding chiral 5-aryl-2-oxazolidinones II in up to 47% yield and 90% ee. Addnl., the origin of enantioselectivity and regioselectivity of the HheC-catalyzed cyanate-mediated ring-opening process was uncovered by single enantiomer bioconversions and mol. docking study. In the experiment, the researchers used many compounds, for example, (S)-4-Phenyloxazolidin-2-one (cas: 99395-88-7Recommanded Product: (S)-4-Phenyloxazolidin-2-one).
(S)-4-Phenyloxazolidin-2-one (cas: 99395-88-7) belongs to oxazolidine derivatives.Oxazolidines are readily available also from propargyl amines. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Recommanded Product: (S)-4-Phenyloxazolidin-2-one
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem