In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Computed Properties of C20H18FNO4, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 189028-93-1, name is (S)-1-(4-Fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione. In an article，Which mentioned a new discovery about 189028-93-1
The invention provides an Ezetimibe synthesis method comprising the following steps: (a) a compound (5) is subjected to asymmetric reduction reaction to obtain a compound (6), and the compound (6) and tert-butyldimethylsilyl chloride react in an organic solution under the action of alkali to obtain a compound (7); (b) the compound (7) and diisopropylethylamine are dissolved in the organic solution, titanium tetrachloride is added in the organic solution to react at 20-50 DEG C, and a compound (3) is added in the organic solution at minus 20 to minus 60 DEG C to react to obtain a compound (8); (c) the compound (8) and N,O-bis(trimethylsilyl) acetamide react in the organic solution at 20-80 DEG C, tetrabutylammonium fluoride trihydrate is added into the organic solution to react at 20-80 DEG C to obtain a compound (9); (d) the compound (9) is subjected to off-protection reaction to obtain Ezetimibe, wherein R is equal to TBS, Ac or COOCH2CCl3. The invention further provides an Ezetimibe intermediate and a preparation method thereof.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 189028-93-1, help many people in the next few years.Computed Properties of C20H18FNO4
Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2792NO – PubChem