The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one( cas:1194-22-5 ) is researched.Quality Control of 6-Hydroxy-2-methylpyrimidin-4(3H)-one.Goh, Eun Mee; Kim, Hyoun-Soo published the article 《The scale up process improvement of 1,1-diamino-2,2-dinitroethane (DADNE)》 about this compound( cas:1194-22-5 ) in New Trends in Research of Energetic Materials, Proceedings of the Seminar, 13th, Pardubice, Czech Republic, Apr. 21-23, 2010. Keywords: explosive diaminodinitroethane synthesis scaleup safety. Let’s learn more about this compound (cas:1194-22-5).
1,1-Diamino-2,2-dinitroethane (DADNE) is a novel explosive with low sensitivity and high performance. The nitration process of 4,6-dihydroxy-2-Me pyrimidine was enhanced using organic solvent. The temperature of reaction in nitration step is preferably 20-40°. The reaction time of step is 2 h. After nitration process, for the hydrolysis of 4,6-dihydroxy-5,5-dinitro-2-dinitromethylene-2,5-dihydropyrimidine, wherein heating reactant is applies in the hydrolysis, thereby solving the safety problem while improving the reaction time of hydrolysis.
There is still a lot of research devoted to this compound(SMILES：CC1=NC(=CC(N1)=O)O)Quality Control of 6-Hydroxy-2-methylpyrimidin-4(3H)-one, and with the development of science, more effects of this compound(1194-22-5) can be discovered.
Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem