Tomas, Loic; Boije af Gennaes, Gustav; Hiebel, Marie Aude; Hampson, Peter; Gueyrard, David; Pelotier, Beatrice; Yli-Kauhaluoma, Jari; Piva, Olivier; Lord, Janet M.; Goekjian, Peter G. published an article in 2012, the title of the article was Total Synthesis of Bistramide A and Its 36(Z) Isomers: Differential Effect on Cell Division, Differentiation, and Apoptosis.Recommanded Product: 168297-86-7 And the article contains the following content:
The total synthesis of bistramide A and its 36(Z),39(S) and 36(Z),39(R) isomers shows that these compounds have different effects on cell division and apoptosis. The synthesis relies on a novel enol ether-forming reaction for the spiroketal fragment, a kinetic oxa-Michael cyclization reaction for the tetrahydropyran fragment, and an asym. crotonylation reaction for the amino acid fragment. Preliminary biol. studies show a distinct pattern of influence of each of the three compounds on cell division, differentiation, and apoptosis in HL-60 cells, thus suggesting that these effects are independent activities of the natural product. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Recommanded Product: 168297-86-7
The Article related to bistramide a isomer preparation antitumor, cell division differentiation apoptosis differential effect bistramide a, enol ether formation total synthesis bistramide a isomer, kinetic oxa michal cyclization total synthesis bistramide a isomer, asym crotonylation total synthesis bistramide a isomer and other aspects.Recommanded Product: 168297-86-7
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem