Application of 102029-44-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.102029-44-7, Name is (R)-4-Benzyl-2-oxazolidinone, molecular formula is C10H11NO2. In a Article£¬once mentioned of 102029-44-7
Synthesis of a smoothened cholesterol: 18,19-Di-nor-cholesterol
Herein, we report the first synthesis of a demethylated form of cholesterol (18,19-di-nor-cholesterol), in which the C18 and C19 methyl groups of the beta-face were eliminated. Recent molecular simulations modeling 18,19-di-nor-cholesterol have suggested that cholesterols opposing rough beta-face and smooth alpha-face play necessary roles in cholesterols membrane condensing abilities and, additionally, that specific facial preferences are displayed as cholesterol interacts with different neighboring lipids and transmembrane proteins. Inspired by these poorly characterized biochemical interactions, an extensive 18-step synthesis was completed as part of a collaborative effort, wherein synthesizing a ?smoothened? cholesterol analogue would provide a direct way to experimentally measure the significance of the beta-face methyl groups. Starting from known perhydrochrysenone A, the synthesis of 18,19-di-nor-cholesterol was accomplished with an excellent overall yield of 3.5%. The use of the highly stereoselective Dieckmann condensation and the employment of Evans chiral auxiliary were both key to ensuring the success of this synthesis.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 102029-44-7
Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H1937NO – PubChem