One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, COA of Formula: C12H21NO4, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 147959-19-1, Name is (S)-tert-Butyl 2,2-dimethyl-4-(2-oxoethyl)oxazolidine-3-carboxylate, molecular formula is C12H21NO4
Stereoselective synthesis of alpha- and beta-L-C-fucosyl aldehydes and their utility in the assembly of C-fucosides of biological relevance
An efficient synthesis of O-benzylated derivatives of the title sugar aldehydes via thiazole addition to tri-O-benzyl-L-fuconolactone followed by highly stereoselective deoxygenation of the resulting thiazolylketose and thiazole to formyl transformation is described. Wittig olefination of these aldehydes with galactopyranose and glucopyranose 6-phosphoranes and reduction of the resulting alkenes afforded alpha- and beta-linked (1?6)-L-C- fucosyl disaccharides, namely, beta-L-C-Fuc-(1?6)-alpha-D-Ga1, alpha-L-C-Fuc-(1?6)-alpha-D-Gal, and alpha-L-C-Fuc-(1?6)- alpha-D-Glc. The alpha-anomer of the above C-fucosyl aldehydes was transformed into a C-fucosylmethyl triphenylphosphonium iodide from which the corresponding C-fucosylmethylene phosphorane was generated upon treatment with BuLi. This phosphorane reacted with the Garner aldehyde (N-Boc D-serinal acetonide) and its one-carbon higher homologue to give alkenes whose reduction and unveiling of the glycinyl group from the oxazolidine ring afforded C-fucosyl alpha-amino acids, namely alpha-L-linked C-fucosyl serines and C-fucosyl asparagines. As a final test of the synthetic utility of the title aldehydes, the beta-anomer was employed as starting material in the stereoselective synthesis of both R- and S-epimer L-C-fucosyl phenylhydroxy acetates. One epimer was obtained by reaction of the sugar aldehyde with phenylmagnesium bromide, oxidation of the resulting alcohol to ketone, addition of 2-lithiothiazole to the latter, and transformation of the thiazole ring into the carboxyl group through an aldehyde intermediate. The other epimer was obtained by the same procedure and inverting the timing of phenyl and thiazolyl group addition. In both routes, the key step establishing the configuration of the quaternary carbon atom of the aliphatic chain was the highly stereoselective addition of the organometal to the ketone intermediate.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. COA of Formula: C12H21NO4, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 147959-19-1, in my other articles.
Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H2340NO – PubChem