So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Fernandez-Saez, Nerea; Rubio-Ruiz, Belen; Campos, Joaquin M.; Unciti-Broceta, Asier; Carrion, Maria Dora; Camacho, Maria Encarnacion researched the compound: 2,6-Dichloropurine( cas:5451-40-1 ).Recommanded Product: 5451-40-1.They published the article 《Purine derivatives with heterocyclic moieties and related analogs as new antitumor agents》 about this compound( cas:5451-40-1 ) in Future Medicinal Chemistry. Keywords: breast colorectal cancer cell purine derivative antitumor; Mitsunobu; antiproliferative activity; apoptosis; benzoxazine; pyridoxazine; quinoline. We’ll tell you more about this compound (cas:5451-40-1).
Identification of new antiproliferative compounds Four series of compounds were synthesized by the Mitsunobu reaction. Their antiproliferative activity was studied against several cancer cells and a noncancerous fibroblast cell line. Their apoptotic activity was analyzed using a caspase 3/7 fluorescence assay. 9-Alkylated-6-halogenated and 2,6-dihalogenated purines show remarkable inhibition of tumor cell proliferation, with the dichloro derivatives being the most potent of all the series. The most promising compound, tetrahydroquinoline 4c, exhibits significant antiproliferative activity against the cancer cells tested, while displaying a 19-fold lower potency against noncancerous fibroblasts, a key feature that indicates potential selectivity against cancer cells. This compound produces a high percentage of apoptosis (58%) after 24 h treatment in human breast cancer MCF-7 cells.
There is still a lot of research devoted to this compound(SMILES：C2=NC1=C(C(=NC(=N1)Cl)Cl)[NH]2)Recommanded Product: 5451-40-1, and with the development of science, more effects of this compound(5451-40-1) can be discovered.
Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem