The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one( cas:1194-22-5 ) is researched.Reference of 6-Hydroxy-2-methylpyrimidin-4(3H)-one.Wu, Yiwen; Mei, Heshan; Zhang, Zhongmin; Lu, Xinying; Yan, Tingren published the article 《Synthesis of antihypertensive moxonidine》 about this compound( cas:1194-22-5 ) in Zhongguo Yaowu Huaxue Zazhi. Keywords: moxonidine preparation antihypertensive. Let’s learn more about this compound (cas:1194-22-5).
Moxonidine was synthesized from acetamidine hydrochloride by cyclizing with di-Et malonate in the presence of Na ethoxide under refluxing for 3 h, nitrifying, chlorinating with POCl3, reducing with Fe/HCl, adding and hydrogenating with 1-acetyl-2-imidazolidone, and methanolysis. The overall yield was 24.8%. The yield of chlorination was 92.8% by using phosphorus oxychloride as the chlorinating agent. The yield of reduction was 87.7% by using iron powder as the reductant and steam distillation as separation method.
In addition to the literature in the link below, there is a lot of literature about this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)Reference of 6-Hydroxy-2-methylpyrimidin-4(3H)-one, illustrating the importance and wide applicability of this compound(1194-22-5).
Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem