Tag: M.W=200-250

Li, Bijin published the artcileUnexpected Sole Enol-Form Emission of 2-(2′-Hydroxyphenyl)oxazoles for Highly Efficient Deep-Blue-Emitting Organic Electroluminescent Devices, Product Details of C9H6BrNO, the publication is Advanced Functional Materials (2017), 27(9), n/a, database is CAplus.

Considerable efforts have been devoted to the development of highly efficient blue light-emitting materials. However, deep-blue fluorescence materials that can satisfy the Commission Internationale de l’Eclairage (CIE) coordinates of (0.14, 0.08) of the National Television System Committee (NTSC) standard blue and, moreover, possess a high external quantum efficiency (EQE) over 5%, remain scarce. Here, the unusual luminescence properties of triphenylamine-bearing 2-(2′-hydroxyphenyl)oxazoles (3a-3c) and their applications in organic light-emitting diodes (OLEDs) are reported as highly efficient deep-blue emitters. The 3a-based device exhibits a high spectral stability and an excellent color purity with a narrow full-width at half-maximum of 53 nm and the CIE coordinates of (0.15, 0.08), which is very close to the NTSC standard blue. The exciton use of the device closes to 100%, exceeding the theor. limit of 25% in conventional fluorescent OLEDs. Exptl. data and theor. calculations demonstrate that 3a possesses a highly hybridized local and charge-transfer excited state character. In OLEDs, 3a exhibits a maximum luminance of 9054 cd m^-2 and an EQE up to 7.1%, which is the first example of highly efficient blue OLEDs based on the sole enol-form emission of 2-(2′-hydroxyphenyl)azoles.

Advanced Functional Materials published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Product Details of C9H6BrNO.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Vinay Kumar, Koravangala S. published the artcileA One-Pot Tandem Approach for the Synthesis of 5-(Het)aryloxazoles from Substituted (Het)aryl Methyl Alcohols and Benzyl Bromides, Name: 5-(4-Bromophenyl)oxazole, the publication is Synlett (2016), 27(9), 1363-1366, database is CAplus.

A new modified van Leusen strategy was developed for the synthesis of biol. significant 5-substituted oxazoles I (R = Ph, 2-furyl, etc.) by the reaction of either [(het)aryl]methyl alcs. RCH₂OH or benzyl bromides RCH₂Br as precursors with tosylmethyl isocyanide (TosMIC) under basic conditions. This method is efficient, takes place under mild reaction conditions, and is tolerant of various functional groups with high yield.

Synlett published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C4H11NO, Name: 5-(4-Bromophenyl)oxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Li, Minyong published the artcileStructure-based discovery and experimental verification of novel Al-2 quorum sensing inhibitors against Vibrio harveyi, Product Details of C9H6BrNO, the publication is ChemMedChem (2008), 3(8), 1242-1249, database is CAplus and MEDLINE.

Quorum sensing has been implicated in the control of pathol. relevant bacterial behavior such as secretion of virulence factors, biofilm formation, sporulation, and swarming motility. The Al-2 quorum sensing pathway is found in both Gram-pos. and Gram-neg. bacteria. Therefore, antagonizing Al-2 quorum sensing is a possible approach to modifying bacterial behavior. However, efforts in developing inhibitors of Al-2-mediated quorum sensing are especially lacking. High-throughput virtual screening using the V. harveyi LuxP crystal structure identified two compounds that were found to antagonize Al-2-mediated quorum sensing in V. harveyi without cytotoxicity. The sulfone functionality of these inhibitors was identified as critical to their ability to mimic the natural ligand in their interactions with Arg215 and Arg310 of the active site.

ChemMedChem published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Product Details of C9H6BrNO.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Yoshizumi, Tomoki published the artcileSynthesis of 2,5-diaryloxazoles through van Leusen reaction and copper-mediated direct arylation, Related Products of oxazolidine, the publication is Tetrahedron Letters (2009), 50(26), 3273-3276, database is CAplus.

The direct arylation of 5-aryloxazoles, prepared by the van Leusen reaction, with various aryl iodides is effectively promoted by a system of CuI combined with PPh₃ and Na₂CO₃ as a ligand and a base, resp., in DMF to produce the corresponding 2,5-diaryloxazoles in good yields.

Tetrahedron Letters published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C8H10O2, Related Products of oxazolidine.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Ok, H. O. published the artcileSubstituted oxazole benzenesulfonamides as potent human β₃ adrenergic receptor agonists, Application In Synthesis of 72571-06-3, the publication is Bioorganic & Medicinal Chemistry Letters (2000), 10(14), 1531-1534, database is CAplus and MEDLINE.

As a part of our investigation into the development of orally bioavailable β₃ adrenergic receptor agonists, we have identified a series of substituted oxazole derivatives that are potent β₃ agonists with excellent selectivity against other β receptors. Several of these compounds showed excellent oral bioavailability in dogs. The cyclopentylethyloxazole (I) is a potent β₃ agonist (EC₅₀=14 nM, 84% activation) with 340-fold and 160-fold selectivity over β₁ and β₂ receptors, resp., and has 38% oral bioavailability in dogs.

Bioorganic & Medicinal Chemistry Letters published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Application In Synthesis of 72571-06-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Vechorkin, Oleg published the artcileThe Nickel/Copper-Catalyzed Direct Alkylation of Heterocyclic C-H Bonds, Category: oxazolidine, the publication is Angewandte Chemie, International Edition (2010), 49(17), 3061-3064, S3061/1-S3061/94, database is CAplus and MEDLINE.

A combination of the Ni complex I and CuI gave efficient coupling of aromatic heterocycles with nonactivated alkyl halides containing a β-hydrogen atom. The chemo- and regioselectivities were excellent. E.g., alkylation of benzoxazole by octyl bromide gave 72% 2-octylbenzoxazole.

Angewandte Chemie, International Edition published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C4Br2N2O4S, Category: oxazolidine.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Mortensen, Deborah S. published the artcileDiscovery and SAR exploration of a novel series of imidazo[4,5-b]pyrazin-2-ones as potent and selective mTOR kinase inhibitors, Recommanded Product: 5-(4-Bromophenyl)oxazole, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(22), 6793-6799, database is CAplus and MEDLINE.

We report here the discovery of a novel series of selective mTOR kinase inhibitors. A series of imidazo[4,5-b]pyrazin-2-ones, represented by screening hit 1, was developed into lead compounds with excellent mTOR potency and exquisite kinase selectivity. Potent compounds from this series show >1000-fold selectivity over the related PI3Kα lipid kinase. Further, compounds such as 2 achieve mTOR pathway inhibition, blocking both mTORC1 and mTORC2 signaling, in PC3 cancer cells as measured by inhibition of pS6 and pAkt (S473).

Bioorganic & Medicinal Chemistry Letters published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Recommanded Product: 5-(4-Bromophenyl)oxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Khan, Anwar Arfien Md. published the artcilePositive and negative modulation of Bombyx mori adenylate cyclase by 5-phenyloxazoles: identification of Octopamine and tyramine receptor agonists, Name: 5-(4-Bromophenyl)oxazole, the publication is Archives of Insect Biochemistry and Physiology (2003), 52(1), 7-16, database is CAplus and MEDLINE.

Nineteen 5-phenyloxazoles (5POs) were examined for their ability to modulate adenylate cyclase by measuring cAMP produced in head membrane homogenates of fifth instar larvae of the silkworm Bombyx mori. Among the compounds tested, 5-(4-methoxyphenyl)oxazole and the 2,6-dichlorophenyl congener showed the highest activation of adenylate cyclase; both compounds produced approx. half the level of cAMP produced by the action of octopamine (OCT). The OCT receptor antagonists chlorpromazine, mianserin, and metoclopramide attenuated 9-stimulated cAMP production In contrast, 5-(4-hydroxyphenyl)oxazole and the 4-cyanophenyl congener attenuated both OCT-stimulated and basal cAMP production The tyramine (TYR) receptor antagonist yohimbine inhibited the neg. effect of 8. These findings indicate that the 5PO class of compounds includes both pos. and neg. modulators of adenylate cyclase in the heads of B. mori larvae, and that 9 and 8 are OCT and TYR receptor agonists, resp. These compounds might prove useful for a pharmacol. dissection of biogenic amine receptors.

Archives of Insect Biochemistry and Physiology published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Name: 5-(4-Bromophenyl)oxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Takahashi, K. published the artcileStructure of oxazolomycin, a new β-lactone antibiotic, Quality Control of 72571-06-3, the publication is Tennen Yuki Kagobutsu Toronkai Koen Yoshishu (1983), 189-96, database is CAplus.

Oxazolomycin (I) [89808-64-0] is a new antitumor antibiotic isolated from Streptomyces sp. (Y-32026). The structural elucidation of this noncrystalline antibiotic has been carried out. Its structure has been determined as I on the basis of spectral anal., x-ray crystallog. anal. and the synthesis of corresponding degraded products. The structure-biol. activity relationship was also studied. In vitro direct cytotoxicity of oxazole derivatives and each segment of oxazolomycin were examined

Tennen Yuki Kagobutsu Toronkai Koen Yoshishu published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C6H12N2O, Quality Control of 72571-06-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Han, Wei published the artcilePalladium-Catalyzed Dehydrogenative Cross-Couplings of Benzazoles with Azoles, Category: oxazolidine, the publication is Angewandte Chemie, International Edition (2011), 50(9), 2178-2182, S2178/1-S2178/58, database is CAplus and MEDLINE.

Unsym. 2,2′-bisheteroaryls are prepared by regioselective C-C coupling between the nonfunctionalized C2 positions of azoles through the cleavage of two C-H bonds. E.g., in the presence of Pd(OAc)₂, Cu(OAc)₂.H₂O, KF, and AgNO₃ under a normal air atm., coupling of benzothiazole and 1-methylimidazole gave 91% 2-(1-methyl-1H-imidazol-2-yl)benzothiazole (I). Formation of homocoupling products was suppressed by the presence of Ag⁺ ions.

Angewandte Chemie, International Edition published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Category: oxazolidine.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem