Tag: M.W=200-250

LaMattina, John L. published the artcileReaction of α-amino ketone hydrochlorides with ortho esters: an oxazole synthesis, Application In Synthesis of 72571-06-3, the publication is Journal of Organic Chemistry (1980), 45(11), 2261-2, database is CAplus.

Reaction of α-amino ketone hydrochlorides with triethyl orthoesters gives 5-monosubstituted and 2,5-disubstituted oxazoles I (R = 4-pyridyl, Ph, p-O₂NC₆H₄, p-BrC₆H₄; R¹ = H, Me, Et). The reaction is most successful when the substituent adjacent to the keto function is electron deficient. Subsequent chem. reactions, however, provide derivatives in which the corresponding electron excessive compounds are available.

Journal of Organic Chemistry published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Application In Synthesis of 72571-06-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Wang, Zhen-Hua published the artcileNickel-catalyzed decarboxylative cross-coupling of indole-3-acetic acids with aryl bromides by convergent paired electrolysis, Application In Synthesis of 72571-06-3, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(59), 8202-8205, database is CAplus and MEDLINE.

Herein, nickel-catalyzed decarboxylative cross-coupling of indole-3-acetic acids with aryl bromides by convergent paired electrolysis was developed in an undivided cell. This protocol features good functional group tolerance, and is chem. redox agent- and sacrificial electrode-free. Mechanistic studies indicated that the base was crucial for the decarboxylation step and a Ni^I/Ni^III catalytic cycle was involved in this transformation.

Chemical Communications (Cambridge, United Kingdom) published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C12H10FeO4, Application In Synthesis of 72571-06-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Yang, Ke published the artcileNickel-Catalyzed Decarboxylative Arylation of Heteroarenes through sp² C-H Functionalization, Category: oxazolidine, the publication is European Journal of Organic Chemistry (2014), 2014(34), 7586-7589, database is CAplus.

The direct decarboxylative arylation of hetereoarenes with benzoic acids through a nickel-catalyzed sp² C-H functionalization process was developed. This process provides the first examples of decarboxylative cross-coupling reactions with aromatic acids through nickel catalysis and tolerates a variety of functional groups. Moreover, this method provides efficient access to 2-aryl-substituted azoles, an important structural unit in natural products, medicinal compounds, and functional materials.

European Journal of Organic Chemistry published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C10H9NO, Category: oxazolidine.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Zhang, Ling-Juan published the artcileTandem cycloaddition-decarboxylation of α-keto acid and isocyanide under oxidant-free conditions towards monosubstituted oxazoles, Related Products of oxazolidine, the publication is RSC Advances (2016), 6(77), 73450-73453, database is CAplus.

An efficient method, tandem [3+2] cycloaddition-decarboxylation of α-keto acid and isocyanide promoted by copper salt was developed. Under oxidant-free conditions, a series monosubstituted oxazoles was constructed. Different from the traditional application of α-oxo acids as acyl surrogates, the elegant approach ingeniously avoided consuming excess oxidants.

RSC Advances published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C25H29N9O3, Related Products of oxazolidine.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Wang, Shuai published the artcileFormal Carbene C-H Bond Insertion in the Cu(I)-Catalyzed Reaction of Bis(trimethylsilyl)diazomethane with Benzoxazoles and Oxazoles, SDS of cas: 72571-06-3, the publication is Organic Letters (2019), 21(6), 1809-1812, database is CAplus and MEDLINE.

A Cu(I)-catalyzed cross-coupling reaction of bis(trimethylsilyl)diazomethane and benzoxazoles/oxazoles is reported. A wide range of functional groups can be tolerated in this transformation. This reaction provides a new method to directly introduce a 1,1-bis(trimethylsilyl)methyl group into heteroaromatic C-H bonds. Subsequent transformations of 1,1-bis(trimethylsilyl)-methylated heteroaromatic compounds are also presented.

Organic Letters published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C12H21NO3, SDS of cas: 72571-06-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Ding, Zhenhua published the artcileCobalt-Catalyzed Addition of Azoles to Alkynes, Quality Control of 72571-06-3, the publication is Organic Letters (2010), 12(18), 4180-4183, database is CAplus and MEDLINE.

A ternary catalytic system consisting of a cobalt salt, a diphosphine ligand, and a Grignard reagent promotes syn-addition of an azole C(2)-H bond across an unactivated internal alkyne with high chemo-, regio-, and stereoselectivities under mild conditions. Mechanistic experiments suggest that the reaction involves oxidative addition of the oxazolyl C-H bond to the cobalt center, alkyne insertion into the Co-H bond, and reductive elimination of the resulting diorganocobalt species.

Organic Letters published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Quality Control of 72571-06-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Yang, Ke published the artcileNickel-catalyzed decarboxylative acylation of heteroarenes by sp² C-H functionalization, Category: oxazolidine, the publication is Chemistry – A European Journal (2014), 20(24), 7241-7244, database is CAplus and MEDLINE.

Nickel-catalyzed ligand-free decarboxylative cross-coupling of azole derivatives with α-oxoglyoxylic acids was developed. This work represents the first example of decarboxylative cross-coupling reactions, in a C-H bond functionalization manner, through nickel catalysis, and tolerates various functional groups. Addnl., this approach provides an efficient access to (ox)azole ketones, an important structural motif in many medicinal compounds with a broad range of biol. activities. © 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemistry – A European Journal published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C8H7NO4, Category: oxazolidine.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Chen, Peng published the artcileDiscovery of novel, potent, isosteviol-based antithrombotic agents, Recommanded Product: 5-(4-Bromophenyl)oxazole, the publication is European Journal of Medicinal Chemistry (2019), 111722, database is CAplus and MEDLINE.

Thrombosis is a pathol. coagulation process and can lead to many serious thrombotic diseases. Here, we report a novel potent antithrombotic compound (6k) based on isosteviol with anticoagulant and antiplatelet activities. 6k selectively inhibited FXa (K_i = 0.015μM) against a panel of serine proteases and showed excellent anticoagulant activity (significant prolongation of ex vivo PT and aPTT over the vehicle, p < 0.01). 6k also significantly inhibited ADP-induced platelet aggregation in rats relative to the vehicle (p < 0.01). Furthermore, 6k exhibited potent ex vivo and in vivo antithrombotic activity in rats relative to the vehicle (p < 0.01 and p < 0.0001, resp.). Novel structure 6k, with potent antithrombotic activity, is expected to lead a promising approach for the development of antithrombotic agents.

European Journal of Medicinal Chemistry published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Recommanded Product: 5-(4-Bromophenyl)oxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Li, Bijin published the artcileDual-emissive 2-(2′-hydroxyphenyl)oxazoles for high performance organic electroluminescent devices: discovery of a new equilibrium of excited state intramolecular proton transfer with a reverse intersystem crossing process, Safety of 5-(4-Bromophenyl)oxazole, the publication is Chemical Science (2018), 9(5), 1213-1220, database is CAplus and MEDLINE.

The photoluminescence (PL) and electroluminescence (EL) properties of two highly efficient excited state intramol. proton transfer (ESIPT) mols., 2-(2′-hydroxyphenyl)oxazoles containing one triphenylamine (TPA) (1) and two TPAs (2) resp., are studied systematically. The enol-forms of both 1 and 2 possess highly hybridized local and charge transfer (HLCT) excited state character, while their excited-state keto-forms are not of obvious HLCT character. A 1-based device exhibits green-white electroluminescence with Commission Internationale de l’Eclairage (CIE) coordinates of (0.25, 0.41) and a high external quantum efficiency (EQE) up to 5.3%, which is the highest EQE value recorded for single mol. white light-emitting materials. A 2-based device shows sky-blue emission with CIE coordinates of (0.18, 0.16) and an EQE of 8.0%, which is the highest EQE in the reported HLCT materials. The fluorescence intensities of the enol-forms of 1 and 2 in EL spectra are increased remarkably relative to their PL spectra. Exptl. data and theor. calculations reveal a new ESIPT equilibrium with a reverse intersystem crossing (RISC) process arising from the HLCT character. In EL, the RISC of the enol-form excitons from the triplet state to the singlet state triggers an increase in the number of enol-form singlet excitons, which further leads to a shift of the ESIPT equilibrium towards an enhanced enol-form emission. Thus, the difference between the ESIPT equilibrium in PL and EL may be ascribed to the HLCT character of the enol-form excited state.

Chemical Science published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Safety of 5-(4-Bromophenyl)oxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Collina, Simona published the artcileEfficient microwave and phosphine-free synthesis of trisubstituted olefins via Heck coupling, Application of 5-(4-Bromophenyl)oxazole, the publication is Letters in Organic Chemistry (2006), 3(1), 16-20, database is CAplus.

We describe an easy and convenient procedure for palladium-catalyzed Heck arylation of disubstituted olefins via microwave irradiation This method of synthesis produces trisubstituted olefins under phosphine-free conditions and in very short times.

Letters in Organic Chemistry published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Application of 5-(4-Bromophenyl)oxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem