Tag: M.W:100-200

Recommanded Product: 6-Hydroxy-2-methylpyrimidin-4(3H)-one. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Methods for improvement of the process of synthesis of 1,1-diamino-2,2-dinitro-ethylene from 6-hydroxy-2-methyl-pyrimidin-4(3H)-one and 2-methyl-2-methoxyimidazolidin-4,5-dione. Author is Kushtaev, Aleksandr A.; Yudin, Nikolai V.; Zbarskii, Vitol’d L.; Zhilin, Viktor F..

The nitration kinetics of 6-hydroxy-2-methyl-pyrimidin-4(3H)-one and 2-methoxy-2-methyl-imidazolidone-4,5-dione was investigated. The hydrolysis kinetics of 2-(dinitro-methylene)-5,5- dinitro-pyrimidine-4,6(1 H,3H,5H)-dione and 2-(dinitro-methylene)-imidazolidone-4,5-dione has been studied. These results can be used for 1,1-diamino-2,2-dinitro-ethene technol. creation.

《Methods for improvement of the process of synthesis of 1,1-diamino-2,2-dinitro-ethylene from 6-hydroxy-2-methyl-pyrimidin-4(3H)-one and 2-methyl-2-methoxyimidazolidin-4,5-dione》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)Recommanded Product: 6-Hydroxy-2-methylpyrimidin-4(3H)-one.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Computed Properties of C5H7BrO3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Addition of malonic esters to azoalkenes generated in situ from α-bromo- and α-chlorohydrazones. Author is Kokuev, Aleksandr O.; Ioffe, Sema L.; Sukhorukov, Alexey Yu..

Michael addition of malonic esters to azoalkenes, generated in situ from α-bromo- and α-chlorohydrazones, has been accomplished. Both aliphatic and aromatic substrates bearing different functional groups were tolerated. The use of a strong base (sodium hydride) for generation of azoalkenes and deprotonation of malonate was found to be essential for a successful coupling. Synthetic potential of the obtained β-hydrazonoalkylmalonates RNHN:C(R1)CH2CH(CO2R2)2 [R = Ac, Boc, Cbz, 2,4-(O2N)2C6H3; R1 = t-Bu, EtO2C, Ph, 2-naphthyl, 2-thienyl, etc.; R2 = Me, PhCH2] was demonstrated by their smooth conversion into five- and six-membered N-heterocycles, functionalized hydrazides, 2-(2-oxo-2-arylethyl)malonates and 2-arylethylmalonates.

《Addition of malonic esters to azoalkenes generated in situ from α-bromo- and α-chlorohydrazones》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Ethyl 3-bromo-2-oxopropanoate)Computed Properties of C5H7BrO3.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one( cas:1194-22-5 ) is researched.Application of 1194-22-5.Jadhav, Pandurang M.; Sarangapani, Radhakrishnan; Patil, Rajendra S.; Pandey, Raj K. published the article 《Process Optimization, Product Profile Mapping, and Intensification of 1,1-Diamino-2,2-dinitroethylene》 about this compound( cas:1194-22-5 ) in Organic Process Research & Development. Keywords: process optimization product profile mapping intensification diaminodinitroethylene safety. Let’s learn more about this compound (cas:1194-22-5).

Industrialization of a chem. process needs an understanding of process chem., optimal process envelope, and the best choice of operation. 1,1-Diamino-2,2-dinitroethylene (FOX-7) is a new generation, and the highly insensitive compound finds application in high-energy formulations as well as preparation of novel high-energy compounds The present study highlights efforts made for establishing a continuous process for FOX-7. The intermediates of nitration of 2-methylpyrimidine-4,6-dione were isolated and characterized by spectroscopic tools. Reaction kinetics was also derived for the formation of intermediates. Product profiles of the reaction were evaluated on deriving expressions for various reactors. The simultaneous effect of heat and reaction was evaluated in a tubular reactor to obtain the runaway reaction condition. The effective reactor scheme was evaluated, designed, and experimented. Process intensification was carried out in a continuous set up comprising various contact patterns. The present study delivered a safe and productive method for FOX-7 processing.

《Process Optimization, Product Profile Mapping, and Intensification of 1,1-Diamino-2,2-dinitroethylene》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)Application of 1194-22-5.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, International Journal of Molecular Sciences called Synthesis, In Vitro and In Silico Anticancer Activity of New 4-Methylbenzamide Derivatives Containing 2,6-Substituted Purines as Potential Protein Kinases Inhibitors, Author is Kalinichenko, Elena; Faryna, Aliaksandr; Bozhok, Tatyana; Panibrat, Alesya, which mentions a compound: 5451-40-1, SMILESS is C2=NC1=C(C(=NC(=N1)Cl)Cl)[NH]2, Molecular C5H2Cl2N4, Application In Synthesis of 2,6-Dichloropurine.

A novel class of potential protein kinase inhibitors 7-16 was synthesized in high yields using various substituted purines. The most promising compounds, 7 and 10, exhibited inhibitory activity against seven cancer cell lines. The IC50 values for compounds 7 and 10 were 2.27 and 2.53 μM for K562 cells, 1.42 and 1.52 μM for HL-60 cells, and 4.56 and 24.77 μM for OKP-GS cells, resp. In addition, compounds 7 and 10 dose-dependently induced the apoptosis and cell cycle arrest at G2/M phase, preventing the cell division of OKP-GS cells. Compounds 7, 9, and 10 showed 36-45% inhibitory activity against PDGFRα and PDGFRβ at the concentration of 1 μM. Mol. modeling experiments showed that obtained compounds could bind to PDGFRα as either type 1 (compound 7, ATP-competitive) or type 2 (compound 10, allosteric) inhibitors, depending on the substituent in the amide part of the mol.

《Synthesis, In Vitro and In Silico Anticancer Activity of New 4-Methylbenzamide Derivatives Containing 2,6-Substituted Purines as Potential Protein Kinases Inhibitors》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,6-Dichloropurine)Application In Synthesis of 2,6-Dichloropurine.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Xu, Yuankang; Wang, Hanyu; Zhao, Jinyan; Yang, Xiaofeng; Pei, Meishan; Zhang, Guangyou; Zhang, Yanxia; Lin, Li published an article about the compound: Ethyl 3-bromo-2-oxopropanoate( cas:70-23-5,SMILESS:O=C(OCC)C(CBr)=O ).Related Products of 70-23-5. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:70-23-5) through the article.

A simple fluorescent schiff base, X, based on imidazo[2,1-b]thiazole-6-carboxylic acid and 3-ethoxy-2-hydroxybenzaldehyde, was designed and synthesized for detection of Zn2+ and PPi. X showed excellent sensitivity and selectivity toward Zn2+ by exhibiting a large fluorescence enhancement (about 42 times). The binding ratio of the X and Zn2+ was 1:1 confirmed by mass spectral anal. and Job′s plot and the association constant between X and Zn2+ was calculated to be 2.2 × 105 M-1. The detection limit was as low as 1.2 × 10-9 M. Moreover, the X[Zn2+] complex could be used as a sensor to detect PPi sensitively and the detection limit was 1.9 × 10-9 M. Furthermore, the fluorescent signals of X were utilized to construct an INHIBIT logic gate at the mol. level. The reason of fluorescence enhancement of X toward Zn2+ was verified by d. functional theory (DFT) and time-dependent d. functional theory (TDDFT) calculations using Gaussian 09.

《A simple fluorescent schiff base for sequential detection of Zn2+ and PPi based on imidazo[2,1-b]thiazole》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Ethyl 3-bromo-2-oxopropanoate)Related Products of 70-23-5.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1194-22-5, is researched, Molecular C5H6N2O2, about The proton magnetic resonance spectra and the structure of 4,6-dihydroxypyrimidine and its derivatives, the main research direction is DIHYDROXYPYRIMIDINES PMR; PYRIMIDINES PMR; HYDROXYPYRIMIDINES PMR.HPLC of Formula: 1194-22-5.

The proton N.M.R. spectra of 4,6-dihydroxypyrimidine and its 2- and 5-substituted derivatives have been compared with the spectra of their O- and N-methyl derivatives of fixed structures, corresponding to possible tautomeric forms. In a Me2SO medium the compounds exist predominantly in the oxohydroxy form. In aqueous solutions of 4,6-dihydroxypyrimidine and its N-methyl derivatives the bipolar-ionic form with delocalized charges probably predominates. 22 references.

《The proton magnetic resonance spectra and the structure of 4,6-dihydroxypyrimidine and its derivatives》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)HPLC of Formula: 1194-22-5.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Shi, Lei; Liu, Yan-Hong; Li, Kun; Sharma, Amit; Yu, Kang-Kang; Ji, Myung Sun; Li, Ling-Ling; Zhou, Qian; Zhang, Hong; Kim, Jong Seung; Yu, Xiao-Qi published an article about the compound: 2,6-Dichloropurine( cas:5451-40-1,SMILESS:C2=NC1=C(C(=NC(=N1)Cl)Cl)[NH]2 ).COA of Formula: C5H2Cl2N4. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:5451-40-1) through the article.

The abnormality of the plasma membrane (PM) is an important biomarker for cell status and many diseases. Hence, visualizing the PM, especially in complex systems, is an emerging field in the life sciences, especially in low-resource settings. Herein, we developed a water-soluble PM-specific probe utilizing electrostatic and hydrophobic interaction strategies with aggregation-induced emission as the signal output. The probe could image the PM with many advanced features (wash-free, ultrafast staining process, excellent PM specificity, and good biocompatibility), which were demonstrated by the PM imaging of neurons. The probe allowed for the first time the imaging of erythrocytes in the complex brain environment through a fluorescence-based method. Moreover, the PM of the epidermal and partial view of the eyeball structure of live zebrafish are also revealed.

《An AIE-Based Probe for Rapid and Ultrasensitive Imaging of Plasma Membranes in Biosystems》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,6-Dichloropurine)COA of Formula: C5H2Cl2N4.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Application of 1194-22-5. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Near-infrared electrophotographic photoreceptor incorporating a hydroxy squaraine. Author is DiPaola-Baranyi, G.; Hsiao, C. K.; Kazmaier, P. M.; Burt, R.; Loutfy, R. O.; Martin, T. I..

The synthesis and xerog. evaluation of bis(4-dimethylamino-2-hydroxy-6-methylphenyl)squaraine (I) is described. Significant photosensitivity enhancement is observed upon addition of certain phenols during the synthesis of the squaraine. Neg. charged dual layer photoreceptor devices incorporating doped I are characterized by excellent xerog. properties such as low dark decay (<50 V/s), high white light and IR sensitivity (E1/2 ≃ 5 ergs/cm2 at 830 nm) and good short-term cycling stability. The effect of charge generator layer thickness, pigment loading and nature of the polymer binder are discussed. 《Near-infrared electrophotographic photoreceptor incorporating a hydroxy squaraine》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)Application of 1194-22-5.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Electric Literature of C5H6N2O2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Effect of pyrimidine derivatives on the incorporation of labeled amino acids into liver proteins. Author is Lifshits, R. I.; Kamilov, F. Kh..

Uracil [66-22-8], cytosine [71-30-7], 6-hydroxy-2,4-dimethylpyrimidine [6622-92-0], 4,6-dihydroxy-2-methylpyrimidine [1194-22-5], 2-amino-6-hydroxy-4-methylpyrimidine [3977-29-5], or 2,5-diamino-6-hydroxy-4-methylpyrimidine [4214-86-2] increased 14C-labeled alanine [56-41-7] incorporation into proteins of the mitochondria-free liver cell fraction when injected i.p. at 100 mg/kg into rats, added at 0.6 mM to the perfusion liquid of the isolated rat liver, or incubated at 0.6 mM with the liver tissue. Orotic acid [65-86-1] had no effect on the liver protein synthesis. The pyrimidine derivatives might affect enzyme synthesis by stimulating DNA-dependent RNA synthesis.

《Effect of pyrimidine derivatives on the incorporation of labeled amino acids into liver proteins》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)Electric Literature of C5H6N2O2.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 5451-40-1, is researched, Molecular C5H2Cl2N4, about Design, synthesis, HER2 inhibition and anticancer evaluation of new substituted 1,5-dihydro-4,1-benzoxazepines, the main research direction is benzenesulfonyl fused azolylbenzoxazepine preparation; HER2 inhibition antitumor SAR pyroptosis induction docking; Antitumour; HER2 receptor; benzoxazepines; molecular modelling; pyroptosis.Safety of 2,6-Dichloropurine.

A series of 11 new substituted 1,5-dihydro-4,1-benzoxazepine derivatives I [X = Y = Z = CH, N; R = H, Cl, Me2N, etc.; R1 = H, Cl; R2 = 4-Me, 4-O2N, 4-O2N] were synthesized to study the influence of the Me group in the 1-(benzenesulfonyl) moiety, the replacement of the purine by the benzotriazole bioisosteric analog, and the introduction of a bulky substituent at position 6 of the purine, on the biol. effects. Their inhibition against isolated HER2 was studied and the structure-activity relationships were confirmed by mol. modeling studies. The most potent compound against isolated HER2 was I [X = Y = N, Z = CH, R = C6H5S, R1 = Cl, R2 = 4-O2N] with an IC50 of 7.31μM. The effects of the target compounds on cell proliferation was investigated. The most active compound was I [X = Y = N, Z = CH, R = R1 = Cl, R2 = 4-Me] against all the tumor cell lines studied (IC50 0.42-0.86μM) does not produce any modification in the expression of pro-caspase 3, but increased the caspase 1 expression and promoted pyroptosis.

《Design, synthesis, HER2 inhibition and anticancer evaluation of new substituted 1,5-dihydro-4,1-benzoxazepines》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,6-Dichloropurine)Safety of 2,6-Dichloropurine.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem