Tag: M.W:100-200

2346-26-1, Oxazolidine-2,4-dione is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of oxazolidine-2,4-dione (0.71 g, 7.03 mmol, prepared according to the method of Liu et al, WO 2006/014262 A2) in toluene (15 mL) in a round bottom flask was added Lawesson’s Reagent (1.71 g, 4.2 mmol). The resulting suspension was heated at reflux for 6 h, and then cooled and stirred at room temperature for an additional 16 h. The suspension was filtered through a short pad of silica gel, and the filtered solids were rinsed with 100 mL of 20% ethyl acetate/hexanes followed by 450 mL of ethyl acetate. The combined filtrates were concentrated under reduced pressure to provide the title compound as a pale yellow solid (0.5 g).1H NMR (CDCl3): delta 9.15 (br s, NH), 5.01 (s, 2H)., 2346-26-1

The synthetic route of 2346-26-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; ZHANG, Wenming; MCCANN, Stephen, Frederick; WO2010/5692; (2010); A2;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

17016-83-0, (S)-4-Isopropyl-2-oxazolidinone is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 5,5,5-trifluoropentanoic acid (5.04 g, 32.3 mmol) inDCM (50 mL) and DMF (3 drops) was added oxalyl chloride (3.4 mL, 38.8 mmol)dropwise over 5 min and the solution was stirred until all bubbling subsided. Thereaction mixture was concentrated under reduced pressure to give pale yellow oil. To aseparate flask charged with a solution of ( 48)-4-(propan-2-yl)-I ,3-oxazolidin-2-one ( 4.I820 g, 32.4 mmol) in THF (IOO mL) at -78 oc was added n-BuLi (2.5M in hexane, 13.0 mL,32.5 mmol) dropwise via syringe over 5 min. After stirring for IO min, the above acidchloride dissolved in THF (20 mL) was added via cannula over I5 min. The reactionmixture was warmed to 0 C, and was allowed to warm to room temperature as the bathwarmed and stirred overnight. To the reaction mixture was added saturated NH4Cl, and25 then extracted with EtOAc (2x). The combined organics were washed with brine, dried(Na2S04), filtered and concentrated under reduced pressure. The crude material waspurified by flash chromatography (Teledyne ISCO CombiFlash Rf, 5% to 60% solventA/B=hexanes/EtOAc, REDISEP Si02 I20g). Concentration of appropriate fractionsprovided Intermediate S-IB (7.39 g, 86%) as a colorless oil: 1H NMR (400 MHz, CDCh) 8 ppm 4.44 (I H, dt, J=8.3I, 3.53 Hz), 4.30 (I H, t, J=8.69 Hz), 4.23 (I H, dd, J=9.06,3.02 Hz), 2.98-3.08 (2 H, m), 2.32-2.44 (I H, m, J=13.9I, 7.02, 7.02, 4.03 Hz), 2.13-2.25(2 H, m), 1.88-2.00 (2 H, m), 0.93 (3 H, d, J=7.05 Hz), 0.88 (3 H, d, J=6.80 Hz)., 17016-83-0

As the paragraph descriping shows that 17016-83-0 is playing an increasingly important role.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; GILL, Patrice; QUESNELLE, Claude A.; SAULNIER, Mark G.; GAVAI, Ashvinikumar V.; WO2014/47369; (2014); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

152305-23-2, (S)-4-(4-Aminobenzyl)oxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLES; Example 1; Preparation of Zolmitriptan (I)(S)-4-(4-Aminobenzyl)-1,3-oxazolidin-2-one (IX) (100 g) was charged in water (400 ml, 4.0 volumes) and conc. HCl (200 ml, 2.0 volumes) was added at 25-30¡ã C. The solution was cooled to 5 to -10¡ã C. and a solution of sodium nitrite (54 g, 1.5 equivalents) in water (400 ml, 4.0 volumes) was added whilst maintaining the temperature below -5¡ã C. After completion of the addition, the reaction mixture was stirred for 3 hours resulting in the formation of the diazonium chloride (XV) in solution., 152305-23-2

152305-23-2 (S)-4-(4-Aminobenzyl)oxazolidin-2-one 7099156, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; GENERICS [UK] LIMITED; US2011/112157; (2011); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

17016-83-0, (S)-4-Isopropyl-2-oxazolidinone is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A suspension of NaH (60%) (253 mg, 6.33 mmol, 1.1 equiv.), previously washed with pentane, in 15 mL of dryTHF was stirred under nitrogen and cooled at 0 C. Oxazolidinone (5.75 mmol, 1 equiv.) was added dropwise,and the reaction was warmed to room temperature. The mixture was stirred for 5 hours at room temperature and0.5 mL of chloroacetyl chloride (0.78 mL, 9.78 mmol, 1.7 equiv.) was added at 0 C. The solution was furtherstirred for 15 h at room temperature. The mixture was filtered and evaporated under reduced pressure. Theresidue was diluted in CH2Cl2, washed with NaHCO3, dried over MgSO4, filtered and concentrated. The crudeproduct 3 was used without further purification.

17016-83-0, 17016-83-0 (S)-4-Isopropyl-2-oxazolidinone 7157133, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Article; Dentel, Helene; Chataigner, Isabelle; Lohier, Jean-Franois; Gulea, Mihaela; Tetrahedron; vol. 68; 10; (2012); p. 2326 – 2335;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2346-26-1,Oxazolidine-2,4-dione,as a common compound, the synthetic route is as follows.

A solution of 1.50 g (6 mmol) of 4-bromobenzyl bromide and 0.73 g (7.2 mmol) of 1,3-oxazolidine-2,4-dione in 6 ml of tetrahydrofuran is admixed dropwise with a solution of 1.39 g (12 mmol) of 1,1,3,3-tetramethylguanidine in 6 ml of tetrahydrofuran. The mixture is stirred at ambient temperature overnight. 50 ml of ice-cold aqueous hydrochloric acid (1N) and 100 ml of ethyl acetate are added. The organic phase is separated after settling out and washed successively with 25 ml of water and 25 ml of saturated aqueous sodium chloride solution. It is dried over sodium sulphate and the filtrate is concentrated under reduced pressure. The residue is purified by chromatography on silica gel, eluting with an 80/20 mixture of cyclohexane and ethyl acetate. 1.14 g of product are obtained in the form of white crystals. m.p. ( C.): 88-90 C.

2346-26-1, The synthetic route of 2346-26-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sanofi-Aventis; US2006/14830; (2006); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80-65-9,3-Aminooxazolidin-2-one,as a common compound, the synthetic route is as follows.,80-65-9

0.5g (4.9mmol) 3-amino oxazolidinone was put in a 25 ml three-necked flask, 10ml 1,2-dimethoxyethane was added, and 1.2g (5.9mmol) n-butyl isocyanate was slowly added dropwise, and then after 30 mins, white solid was precipitated, and the mixture was heated under refluxing for 15 mins, filtrated under vacuum, and recrystallized in isopropanol, to get 0.61g white solid (Compound 15), with a yield of 62%. 1H-NMR(400MHz,DMSO)deltappm:8.01(1H,s),6.69(1H,s),4.30(2H,t,J=8.0Hz,J=8.0Hz ),3.59(2H,t,J=8.0Hz,J=8.0Hz),3.00(2H,m),1.37(2H,m),1.25(2H,m),0.87(3H,m);EI-MS( m/z): 202.2[M+H]+; m.p. 98-100C.

As the paragraph descriping shows that 80-65-9 is playing an increasingly important role.

Reference£º
Patent; Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China; LI, Song; XIAO, Junhai; ZHAO, Mingming; ZHONG, Wu; WANG, Lili; ZHENG, Zhibing; XIE, Yunde; LI, Xingzhou; ZHAO, Guoming; ZHOU, Xinbo; WANG, Xiaokui; CHEN, Wei; EP2952509; (2015); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

95530-58-8,95530-58-8, (R)-4-Isopropyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The R type EvansAuxiliary base addedTo 250 ml of dry reaction flask,70 ml of anhydrous THF dissolved,Cooled to -78 C,And then slowly adding n-BuLi (18.5 ml, 46.3 mmol)After 30 min reaction,(E) -2-methyl-2-butenoyl chloride (5.0 g, 42.5 mmol) was added and reacted for 30 min. The temperature was raised to 0 C and the reaction was continued for 15 min.20ml saturated ammonium chloride quenching reaction, separationThe organic phase was extracted with ethyl acetate (20 ml x 3). The organic phases were combined, washed with saturated brine (40 ml), dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure.The residue was subjected to column chromatography (elution conditions, petroleum ether: ethyl acetate = 10: 1) to give the product as a white solid, 7.7 g, 94% yield;

The synthetic route of 95530-58-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Fudan University; Lei Xinsheng; Lin Guoqiang; Zhao Qun; Xu Qianqian; Shan Guangsheng; (20 pag.)CN104418707; (2017); B;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

80-65-9, 3-Aminooxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,80-65-9

[Example 1] 4-fluoro-N-(2-oxo-oxazolidin-3-yl)benzamide (Compound 1) 0.5g (4.9mmol) 3-amino oxazolidinone was put in a 25ml three-necked flask, 10ml water was added, and 0.92g (5.9mmol) 4-fluorobenzoyl chloride was added slowly dropwise at room temperature, the reactiong system was stirred overnight. White precipitate was precipitated, filtrated under vacuum, and recrystallized in ethanol to get white solid (Compound 1) 0.61g, with a yield of 56%. 1H-NMR(400MHz,DMSO)deltappm:10.87(1H,s),7.97(2H,t,J=4.0Hz,J=4.0Hz),7.40 (2H,t,J=8.0Hz,J=12.0Hz),4.46(2H,t,J=8.0Hz,J=8.0Hz), 3.79(2H,t,J=8.0Hz,J=8.0Hz); EI-MS(m/z):225.1[M+H]+; m.p.189-192C.

80-65-9 3-Aminooxazolidin-2-one 65725, aoxazolidine compound, is more and more widely used in various.

Reference£º
Patent; Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China; LI, Song; XIAO, Junhai; ZHAO, Mingming; ZHONG, Wu; WANG, Lili; ZHENG, Zhibing; XIE, Yunde; LI, Xingzhou; ZHAO, Guoming; ZHOU, Xinbo; WANG, Xiaokui; CHEN, Wei; EP2952509; (2015); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.695-53-4,5,5-Dimethyloxazolidine-2,4-dione,as a common compound, the synthetic route is as follows.

695-53-4, To a solution of 7-(3-ethyl-heptyl)-6-(4-formyl-phenoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-2- carbonitrile (720 mg, 1.90 MMOL) in MeOH (30 ml) and THF (30 ml) is added portionwise NaBH4 (100 mg, 2.60 MMOL). The reaction mixture is stirred at rt for 4 h, and the bulk of solvents are removed in vacuo. The residue is diluted with water, and extracted with CH2CI2. The combined organic extracts are washed with brine, and dried over NA2S04, filtered, and concentrated in vacuo. The residue is purified by silica gel column chromatography to give the alcohol 7-(3-ethyl-heptyl)-6-(4-hydroxy-methyl-phenoxymethyl)-7h-pyrrolo[2,3- d]pyrimidine-2-carbonitrile. To a solution of said, alcohol (140 mg, 0.36 MMOL), 5,5-dimethyl-oxazolidinedione (46 mg, 360 MMOL), and Ph3P (105 mg, 0.40 MMOL) in THF (2 mL) is added DEAD (0.25 ml, 0.46 MMOL). The reaction mixture is stirred at rt for overnight. After concentration, the residue is purified by RP-HPLC to give the title compound; Rf 0. 38 (n- Hexane: EtOAc=1: 1) ;H-HMR (400 MHz) 0.92-1. 00 (m, 2H), 1. 18-1. 25 (m, 3H), 1. 30-1. 40 (m, 1H), 1. 58 (s, 6H), 1. 68-1. 78 (m, 7H), 4.35-4. 39 (m, 2H), 4.62 (s, 2H), 5.22 (s, 2H), 6. 71 (s, 1H), 6. 95 (dd, 2H), 7.37 (dd, 2H), 8. 96 (s, 1H).

The synthetic route of 695-53-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2004/69256; (2004); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80-65-9,3-Aminooxazolidin-2-one,as a common compound, the synthetic route is as follows.,80-65-9

Example 8; Preparation of Compound 35; N-(4-chloro-2-propionylphenyl)-trifluoromethanesulfonamide (2.50 g, 7.9 mmol) and 3-amino-2-oxazolidinone (1.225 g, 11.85 mmol) were mixed in toluene (30 mL). The reaction was heated, with a Dean-Stark apparatus to remove water, at reflux for 3 hrs. The reaction mixture was cooled and evaporated to dryness. The residue was purified on a silica column using 20-100% CH2Cl2/PE, followed by 2% MeOH/DCM as solvent. The product was then recrystallized from DCM/PE to give 2.20 g of white solid. M.p. 115-117 C. 1H n.m.r. (CDCl3) delta 11.82, 1H, b; 7.69, 1H, d, J8.9 Hz; 7.60, 1H, d, J2.2 Hz; 7.42, 1H, dd, J18.9 Hz, J22.3 Hz; 4.54, 2H, t, J7.4 Hz; 3.96, 2H, t, J7.4 Hz; 2.93, 2H, q, J7.6 Hz; 1.13, 3H, t, J7.6 Hz.

The synthetic route of 80-65-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Winzenberg, Kevin Norman; Meyer, Adam Gerhard; Yang, Qi; Riches, Andrew Geoffrey; US2007/238700; (2007); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem