80-65-9, 3-Aminooxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,80-65-9
Following the addition of 4-(4-fluorophenoxy) butyric acid (0.71 g, 3.6 mmol) to 20 mL ofdichloromethane in a 50 mL three-necked round-bottom flask, thesolution was agitated until dissolution. Subsequently, EDCI (0.85 g,4.44 mmol) HOBt (0.6 g, 4.44 mmol) and triethylamine (0.84 g,9.25 mmol) were added in turn at 0 C. Stirring in an ice bath for 1 h,3-amino-2-oxazolidinone (0.37 g, 3.6 mmol) was added again. Thesolutionwas brought to 25 C and stirred overnight. Following TLC,the product was filtered by vacuum and dried under rotary evaporation.The product was a white solid weighing 0.51 g with a yieldof 50.2%. 1H NMR (400 MHz, DMSO-d6) delta 10.16 (s, 1H), 7.07 (t,J 12 Hz, 2H), 6.92 (d, J 12 Hz, 2H), 4.36 (t, J 8.0 Hz, 2H), 3.93 (t,J 8.0 Hz, 2H), 3.63 (t, J 8.0 Hz, 2H), 2.26 (t, J 8.0 Hz, 2H), 1.97-1.86 (m, 2H); 13C NMR (DMSO-d6): delta 171.81, 158.02, 157.65, 129.72,124.48, 116.62, 68.15, 62.06, 46.36, 33.34, 28.78, 25.46, 25.02. HRMS(ESI) m/z: calcd. for C13H15FN2O4 [M + H]: 283.1094, found:283.1088.
As the paragraph descriping shows that 80-65-9 is playing an increasingly important role.
Reference£º
Article; Jiang, Kai; Yan, Xinlin; Yu, Jiahao; Xiao, Zijian; Wu, Hao; Zhao, Meihua; Yue, Yuandong; Zhou, Xiaoping; Xiao, Junhai; Lin, Feng; European Journal of Medicinal Chemistry; vol. 194; (2020);,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem