Tag: 452339-73-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.452339-73-0,(R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one,as a common compound, the synthetic route is as follows.,452339-73-0

A solution of (5R)-5- (2, 2-dimethyl-4H-1, 3-benzodioxin-6-yl)-1, 3-oxazolidin-2-one (EXAMPLE 1VI) (500mg) in DMF (15ML) under nitrogen at 0 was treated with sodium hydride (60% dispersion in mineral oil, 96mg) and the mixture stirred at 20 for 10 min. A SOLUTION OF 6-BROMOHEXYL 4-PENTYN-1-YL ether (WO 02/066422) (545mg) in DMF (1 ML) was added and the mixture stirred at 20 for 18 h. Phosphate buffer solution (pH 6. 5) and water were added and the mixture was extracted with EtOAc. The extract was washed with water and dried (NA2SO4). Solvent EVAPORATION IN VACUO gave a residue, which was purified by flash chromatography on silica gel. Elution with EtOAc-PE (2: 3) gave the title compound (700mg). LCMS RT = 3.48min.

As the paragraph descriping shows that 452339-73-0 is playing an increasingly important role.

Reference£º
Patent; GLAXO WELLCOME HOUSE; WO2004/37773; (2004); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.452339-73-0,(R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one,as a common compound, the synthetic route is as follows.,452339-73-0

A solution of (5R)-5-(2, 2-dimethyl-4H-1, 3-benzodioxin-6-yl)-1, 3-oxazolidin-2-one (82mg) in DMF under nitrogen was treated with sodium hydride (60% dispersion in mineral oil, 16mg) and the mixture stirred at 200 for 10min. A solution of 1- (2-bromoethyl)-4- (4- phenylbutoxy) benzene (110mg) in DMF (1ml) was added and the mixture was stirred at 20C for 2h. Phosphate buffer solution (pH 6.5, 10ml) and water (20ml) were added and the mixture was extracted with EtOAc. The combined extracts were washed with water and dried (Na2SO4). Solvent evaporation in vacuo gave a residue which was partially purified by SPE (5g). Elution with DCM then EtOAC-cyclohexane (1: 1) gave material which was further purified by flash chromatography on silica gel. Elution with EtOAc- petroleum ether (3: 2) gave the title compound (75g). LCMS RT = 3.92min.

The synthetic route of 452339-73-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2003/91204; (2003); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.452339-73-0,(R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one,as a common compound, the synthetic route is as follows.

Sodium hydride (60% dispersion in oil 1.26 g) was added to a stirred, cooled (ice-bath) solution of (5R)-5-(2, 2-dimethyl-4H-1, 3-benzodioxin-6-yl)-2-oxazolidinone (5.47 g) in dry DMF (50 [ML)] under nitrogen and the mixture was stirred for 15 min at 5 [C.] A solution of 6-bromohexyl [4- (3-IODOPHENYL) BUTYL] ether (10.7 g) in DMF (30 ml) was then added dropwise over 10 min. The mixture was stirred for 2 h at ambient temperature, then poured into aqueous solution of ammonium chloride and extracted into ethyl acetate. The combined extracts were washed with water, dried [(NA2SO4)] and evaporated. The residue was purified on biotage (90 g cartridge) eluting with ether-hexane (3: 2) to give the title compound (9.8 g). LCMS RT= 4.20 min.

As the paragraph descriping shows that 452339-73-0 is playing an increasingly important role.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/22547; (2004); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

452339-73-0, (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 10 Preparation of (R)-3-{6-[2-(2,6-Dichlorobenzyloxy)-ethoxy]-hexyl}-5-(2,2-di methyl-4H-benzo[1,3]dioxin-6-yl)-oxazolidin-2-one (XIII) Potassium tert-butoxide (1.0eqt) was added to a solution of Compound IX (1.0eqt) in DMF (7V) under N2 and the reaction stirred for 1 h at ambient temperature. A solution of compound XII (1.0eqt) in anhydrous DMF (1.5V) was added to the above reaction mass and the reaction allowed stirring at ambient temperature for 3 hr. The reaction mixture was diluted with ice/water and extracted with ethyl acetate. The organic layer was separated then washed successively with water/saturated brine and dried over sodium sulfate. The solution was concentrated to dryness and the residue thus obtained was purified by column chromatography (EtOAc-hexane). The pure fractions were concentrated under vacuum to afford the title compound as pale yellow color oil. Yield: 91%; purity by HPLC: 99.24%; Chiral purity: R-isomer: 99.96%; S-isomer: 0.04%

The synthetic route of 452339-73-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PERRIGO API LTD.; Dammalapati, Venkata Lakshmi Narasimha Rao; Mudduluru, Hari Krishna; Aduri, Ravindra; US2015/239862; (2015); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem