Tag: 221.2524

Metformin and Other Pharmaceuticals Widespread in Wadeable Streams of the Southeastern United States was written by Bradley, Paul M.;Journey, Celeste A.;Button, Daniel T.;Carlisle, Daren M.;Clark, Jimmy M.;Mahler, Barbara J.;Nakagaki, Naomi;Qi, Sharon L.;Waite, Ian R.;Van Metre, Peter C.. And the article was included in Environmental Science & Technology Letters in 2016.Formula: C12H15NO3 This article mentions the following:

Pharmaceutical contaminants are growing aquatic-health concerns and largely attributed to wastewater treatment facility (WWTF) discharges. Five biweekly water samples from 59 small Piedmont (USA) streams were analyzed for 108 pharmaceuticals and degradates using high-performance liquid chromatog. and tandem mass spectrometry. The antidiabetic metformin was detected in 89% of samples and at 97% of sites. At least one pharmaceutical was detected at every site (median of 6, maximum of 45), and several were detected at ≥10% of sites at concentrations reported to affect multiple aquatic end points. Maximal cumulative (all detected compounds) concentrations per site were 17-16000 ng/L. Watershed urbanization, water table depth, soil thickness, and WWTF metrics correlated significantly with instream pharmaceutical contamination. Comparable pharmaceutical concentrations and detections at sites with and without permitted wastewater discharges demonstrate the importance of non-WWTF sources and the need for broad-scale mitigation. The results highlight a fundamental biochem. link between global human-health crises like diabetes and aquatic ecosystem health. In the experiment, the researchers used many compounds, for example, 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one (cas: 1665-48-1Formula: C12H15NO3).

5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one (cas: 1665-48-1) belongs to oxazolidine derivatives.Oxazolidines are readily available also from propargyl amines. Some reports highlighted again the effectiveness of oxazolidine-based compounds in driving the stereo- or diastereotopic outcome of chemical reactions.Formula: C12H15NO3

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Decarboxylative sp³ C-N coupling via dual copper and photoredox catalysis was written by Liang, Yufan;Zhang, Xiaheng;MacMillan, David W. C.. And the article was included in Nature (London, United Kingdom) in 2018.Quality Control of 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one This article mentions the following:

Over the past three decades, considerable progress has been made in the development of methods to construct sp² carbon-nitrogen (C-N) bonds using palladium, copper or nickel catalysis. However, the incorporation of alkyl substrates to form sp³ C-N bonds remains one of the major challenges in the field of cross-coupling chem. Here we demonstrate that the synergistic combination of copper catalysis and photoredox catalysis can provide a general platform from which to address this challenge. This cross-coupling system uses naturally abundant alkyl carboxylic acids and com. available nitrogen nucleophiles as coupling partners. It is applicable to a wide variety of primary, secondary and tertiary alkyl carboxylic acids (through iodonium activation), as well as a vast array of nitrogen nucleophiles: nitrogen heterocycles, amides, sulfonamides and anilines can undergo C-N coupling to provide N-alkyl products in good to excellent efficiency, at room temperature and on short timescales (five minutes to one hour). We demonstrate that this C-N coupling protocol proceeds with high regioselectivity using substrates that contain several amine groups, and can also be applied to complex drug mols., enabling the rapid construction of mol. complexity and the late-stage functionalization of bioactive pharmaceuticals. In the experiment, the researchers used many compounds, for example, 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one (cas: 1665-48-1Quality Control of 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one).

5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one (cas: 1665-48-1) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Quality Control of 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

C-H heteroarylation of aromatics via catalyst free S_N2′ coupling cycloaromatization was written by Lu, Qixing;Wang, Tao;Wu, Qian;Cheng, Lijing;Luo, Han;Liu, Lei;Chu, Guobiao;Wang, Lufeng;Li, Baosheng. And the article was included in Green Chemistry in 2022.Reference of 1665-48-1 This article mentions the following:

The construction of a carbon-carbon bond is the most fundamental aspect of synthetic chem. In this study, authors developed a catalyst-free S_N2′ reaction of β-OTf-substituted enamides with aromatics to obtain aryl-substituted aza-1,4-dicarbonyl compounds that can be in situ transformed into aryl-imidazole, aryl-thiazole, and aryl-oxazole in one-pot operation, thus achieving C-H heteroarylation of aromatics This simple, efficient, clean and scalable strategy, which provides difficult-to-realize biaryl products, is compatible with various aromatics having varying complexities. This method can be used for the late-stage modification of various com. pharmaceuticals or functional materials and offers an orthogonal approach for constructing biaryl compounds In the experiment, the researchers used many compounds, for example, 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one (cas: 1665-48-1Reference of 1665-48-1).

5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one (cas: 1665-48-1) belongs to oxazolidine derivatives. Oxazolidine-based compounds are well-known chiral auxiliaries and strategic molecular moieties in chemistry since they can effectively mask or mimic amino acid units or amino alcohols. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Reference of 1665-48-1

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Bioanalytical method development, validation and quantification of Bosentan by high-performance liquid chromatography in rat plasma was written by Nallakumar, P.;Siva, Kumar R.. And the article was included in World Journal of Pharmaceutical Research in 2017.Category: oxazolidine This article mentions the following:

A Simple and rapid bioanal. high performance liquid chromatog. (HPLC) method for the determination of Bosentan using Losertan as an internal standard was developed and validated as per regulatory requirements. Sample preparation was accomplished through liquid phase extraction and chromatog. separation on a reverse phase column. The mobile phase consists of mixture of methanol and water in the ratio of 50:50 at a flow rate of 1ml/min. The wavelength used for the detection of bosentan was 225 nm with a total run time of 6 min. The retention times of bosentan and losartan were found to be 2 and 4 resp. The method was developed and tested for the linearity range of 250-750mg/mL. The method was validated for accuracy, precision, linearity and recovery in compliance to international regulatory guidelines. In the experiment, the researchers used many compounds, for example, 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one (cas: 1665-48-1Category: oxazolidine).

5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one (cas: 1665-48-1) belongs to oxazolidine derivatives. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Category: oxazolidine

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Emerging pollutants and antibiotics removed by conventional activated sludge followed by ultraviolet radiation in a municipal wastewater treatment plant in Mexico was written by Martinez-Organiz, Angeles;Bravo, Jose Elias Becerril;Llompart, Maria;Dagnac, Thierry;Lamas, J. Pablo;Vazquez, Lua;Sampedro-Rosas, Laura. And the article was included in Water Quality Research Journal in 2021.Quality Control of 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one This article mentions the following:

Different groups of emerging pollutants (EPs) were identified (drugs, pesticides, hormones, illicit drugs, and fire retardant), and the removal of four antibiotics was determined (sulfamethoxazole 62.2-94.4%, ciprofloxacin 71-83.1%, norfloxacin 82-89%, and ofloxacin 78-97.9%) in a municipal wastewater treatment plant (WWTP) in Acapulco, Gro. Mexico. The compounds were extracted from influent and effluent samples by solid phase extraction (SPE). The identification of non-target EPs was performed by liquid chromatog. coupled with high-resolution mass spectrometry (LC-HRMS). The antibiotic quantification was performed by liquid chromatog. coupled with tandem mass spectrometry (LC-MS/MS). Most of the non-target compounds were detected only in the influent samples. Antibiotics levofloxacin and nalidixic acid, the anticonvulsants carbamazepine and oxycarbamazepine, the local anesthetic lidocaine, and the pesticide tridemorph were the main EPs not removed by the WWTP. In this study, it was shown that the Aguas Blancas WWTP does not manage to remove 100% of the various EPs identified in the effluent, although the elimination degree is high in most cases, despite being one of the model plants in Mexico. In the experiment, the researchers used many compounds, for example, 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one (cas: 1665-48-1Quality Control of 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one).

5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one (cas: 1665-48-1) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries.Quality Control of 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Simultaneous quantitative analysis of 39 common toxicological drugs for increased efficiency in an ante- and postmortem laboratory was written by Mata, Dani C.;Davis, John F.. And the article was included in Forensic Science International in 2022.Related Products of 1665-48-1 This article mentions the following:

A novel forensic method was developed to quantitate 39 drugs of toxicol. interest for ante-mortem and postmortem anal. This method was created to combine and replace four existing quantitation methods as well as add three addnl. compounds of interest and serves to drastically increase the efficiency of the criminalists and reduce the case backlog. The method is currently applied to ante-mortem blood, postmortem blood, urine, liver, brain, and gastric contents. The extraction was performed by using a protein precipitation and DPX WAX-S tips with anal. on a Waters i-class Acquity ultra-performance liquid chromatog. with a Phenomenex Kinetex Column (1.7μm Biphenyl Å, 2.1 x100 mm) followed by a Waters XeVo-TQS tandem mass spectrometer using pos. electrospray ionization in multiple reaction monitor mode. The sample volume required for anal. was 0.5 mL, or 0.5 g, an improvement from 4 mL when performing previous methods utilized in the laboratory The improved method incorporated the 2017 recommended cut-offs for toxicol. investigation of driving under the influence of drugs and was validated following the SWGTOX and ANSI/ASB guidelines of method validation. The advantages of analyzing low volume cases and/or detecting drugs previously outside the laboratorys scope of anal., (such as gabapentin, pregabalin and baclofen) will be presented in two case studies. The multi-drug quantitation method allowed for the anal. of 39 drugs including a hydrolysis step, if needed, with only 0.5 mL or 0.5 g of sample. The method condensed two previously un-validated quant. methods and two addnl. qual. methods, which detected many commonly seen drugs, all into a single method. Three addnl. analytes of interest, gabapentin, pregabalin and baclofen, which it had previously been unable to detect, were added to the new method. The added benefit of these new drugs added both the coroners investigators in cause of death determination and driving under the influence of drugs investigation especially with the high prevalence of gabapentin. In the experiment, the researchers used many compounds, for example, 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one (cas: 1665-48-1Related Products of 1665-48-1).

5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one (cas: 1665-48-1) belongs to oxazolidine derivatives.Oxazolidines are readily available also from propargyl amines. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Related Products of 1665-48-1

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem