Tag: 187.1947

Gold(I)-Catalyzed [8+2]-Cycloaddition of 8-Aryl-8-azaheptafulvenes with Allenamides and Ynamides: Regioselective Synthesis of Dihydrocycloheptapyrrole Derivatives was written by Suarez-Rodriguez, Tatiana;Suarez-Sobrino, Angel L.;Ballesteros, Alfredo. And the article was included in Chemistry – A European Journal in 2021.Recommanded Product: 3-(Phenylethynyl)oxazolidin-2-one This article mentions the following:

Gold(I)-catalyzed higher-order [8+2] cycloadditions of 8-aryl-8-azaheptafulvenes with allenamides and ynamides were studied. 1,8-Dihydrocycloheptapyrroles were achieved by a regioselective [8+2] cycloaddition of azaheptafulvenes and allenamides in the presence of (2,4-ditBuC₆H₃O)₃PAuNTf₂ as catalyst. Besides, ynamides and 8-aryl-8-azaheptafulvenes, undergo a regioselective [8+2] cycloaddition, to give 2-amido-1,4-dihydrocycloheptapyrroles in the presence of JohnPhosAuNTf₂ as catalyst. Both reactions take place with good yields and with a variety of substituents. A plausible mechanism hypothesis suggests a nucleophilic attack of the 8-azaheptafulvene to the gold activated electron rich allene or alkyne moieties of the allenamide and ynamide, resp. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Recommanded Product: 3-(Phenylethynyl)oxazolidin-2-one).

3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives.Oxazolidines are readily available also from propargyl amines. Some reports highlighted again the effectiveness of oxazolidine-based compounds in driving the stereo- or diastereotopic outcome of chemical reactions.Recommanded Product: 3-(Phenylethynyl)oxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Copper-Catalyzed Silylcupration of Activated Alkynes was written by Vercruysse, Sebastien;Jouvin, Kevin;Riant, Olivier;Evano, Gwilherm. And the article was included in Synthesis in 2016.Computed Properties of C11H9NO2 This article mentions the following:

A highly efficient catalytic silylcupration of activated alkynes is reported. Upon reaction with silylboronates and methanol in THF at room temperature in the presence of copper(I) fluoride tris(triphenylphosphine), a range of ynamides and propiolates were found to undergo a smooth silylcupration. This reaction, which tolerates various functional groups, affords a straightforward and efficient entry to the corresponding β-silylenamides and -acrylates, which were formed with high levels of regio- and stereoselectivities. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Computed Properties of C11H9NO2).

3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. Some reports highlighted again the effectiveness of oxazolidine-based compounds in driving the stereo- or diastereotopic outcome of chemical reactions.Computed Properties of C11H9NO2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Iodine-Mediated Oxidation of Ynamides: A Facile Access to N-Monosubstituted α-Ketoamides and α-Ketoimides was written by Huang, Hai;He, Guangke;Zhu, Xiaolin;Jin, Xiaodong;Qiu, Shineng;Zhu, Hongjun. And the article was included in European Journal of Organic Chemistry in 2014.Related Products of 888329-88-2 This article mentions the following:

An efficient iodine-mediated oxidation reaction for ynamides has been developed to produce N-monosubstituted α-ketoamides and α-ketoimides. This oxidative method, which exhibits good functional group tolerance, was performed under mild conditions without a metal catalyst. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Related Products of 888329-88-2).

3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries. Some reports highlighted again the effectiveness of oxazolidine-based compounds in driving the stereo- or diastereotopic outcome of chemical reactions.Related Products of 888329-88-2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Cp*Co(III)-Catalyzed oxidative [5+2] annulation: regioselective synthesis of 2-aminobenzoxepines via C-H/O-H functionalization of 2-vinylphenols with ynamides was written by Han, Xiang-Lei;Liu, Xu-Ge;Lin, E.;Chen, Yunyun;Chen, Zhuangzhong;Wang, Honggen;Li, Qingjiang. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2018.Computed Properties of C11H9NO2 This article mentions the following:

A Cp*Co(III)-catalyzed [5+2] C-H annulation reaction of 2-vinylphenols with ynamides was developed. The reaction led to the efficient synthesis of valuable 2-aminobenzoxepines in high regioselectivity. Mild reaction conditions, good functional group tolerance, and moderate to good yields were observed The synthetic utility was demonstrated by a gram-scale synthesis and further transformations of the products. Preliminary mechanistic studies were conducted, and a possible catalytic cycle was proposed. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Computed Properties of C11H9NO2).

3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Computed Properties of C11H9NO2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Yb(III)-catalysed syn-thioallylation of ynamides was written by Gogoi, Manash Protim;Vanjari, Rajeshwer;Prabagar, B.;Yang, Shengwen;Dutta, Shubham;Mallick, Rajendra K.;Gandon, Vincent;Sahoo, Akhila K.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021.Computed Properties of C11H9NO2 This article mentions the following:

The syn-thioallylation of ynamides I (R = Ph, 4-methylphenyl, 3-cyanophenyl, etc.) to give products incorporating a sulfide moiety at the α-position and an allyl group at the β-position of the ynamide was reported. The transformation is successful under ytterbium(III)-catalysis, providing access to highly substituted thioamino-skipped-dienes II (R¹ = 2-propenyl, Ph, 2-fluorophenyl, naphthalen-2-yl, etc.) with broad substrate scope. Thus, tetrasubstituted olefins II (with four different functional groups: amide, Ph, thioaryl/alkyl, and allyl on the carbon centers) are made in a single step from readily accessible ynamides I preserving complete atom economy. The reaction can be extended to the synthesis of selenoamino diene III by ynamide I (Ar = Ph) syn-selenoallylation. DFT studies and control experiments provide insight into the reaction mechanism. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Computed Properties of C11H9NO2).

3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol. Oxazolidines are weaker bases (pKa 6–7) than parent β-amino alcohols and found to be more lipophilic than the parent compound at physiological pH.Computed Properties of C11H9NO2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Yb(III)-catalysed syn-thioallylation of ynamides was written by Gogoi, Manash Protim;Vanjari, Rajeshwer;Prabagar, B.;Yang, Shengwen;Dutta, Shubham;Mallick, Rajendra K.;Gandon, Vincent;Sahoo, Akhila K.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021.Computed Properties of C11H9NO2 This article mentions the following:

The syn-thioallylation of ynamides I (R = Ph, 4-methylphenyl, 3-cyanophenyl, etc.) to give products incorporating a sulfide moiety at the α-position and an allyl group at the β-position of the ynamide was reported. The transformation is successful under ytterbium(III)-catalysis, providing access to highly substituted thioamino-skipped-dienes II (R¹ = 2-propenyl, Ph, 2-fluorophenyl, naphthalen-2-yl, etc.) with broad substrate scope. Thus, tetrasubstituted olefins II (with four different functional groups: amide, Ph, thioaryl/alkyl, and allyl on the carbon centers) are made in a single step from readily accessible ynamides I preserving complete atom economy. The reaction can be extended to the synthesis of selenoamino diene III by ynamide I (Ar = Ph) syn-selenoallylation. DFT studies and control experiments provide insight into the reaction mechanism. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Computed Properties of C11H9NO2).

3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol. Oxazolidines are weaker bases (pKa 6–7) than parent β-amino alcohols and found to be more lipophilic than the parent compound at physiological pH.Computed Properties of C11H9NO2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Cp*Co(III)-Catalyzed oxidative [5+2] annulation: regioselective synthesis of 2-aminobenzoxepines via C-H/O-H functionalization of 2-vinylphenols with ynamides was written by Han, Xiang-Lei;Liu, Xu-Ge;Lin, E.;Chen, Yunyun;Chen, Zhuangzhong;Wang, Honggen;Li, Qingjiang. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2018.Computed Properties of C11H9NO2 This article mentions the following:

A Cp*Co(III)-catalyzed [5+2] C-H annulation reaction of 2-vinylphenols with ynamides was developed. The reaction led to the efficient synthesis of valuable 2-aminobenzoxepines in high regioselectivity. Mild reaction conditions, good functional group tolerance, and moderate to good yields were observed The synthetic utility was demonstrated by a gram-scale synthesis and further transformations of the products. Preliminary mechanistic studies were conducted, and a possible catalytic cycle was proposed. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Computed Properties of C11H9NO2).

3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Computed Properties of C11H9NO2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem