Tag: 187.1947

Gold-Catalyzed Intermolecular Nitrene Transfer from 2H-Azirines to Ynamides: A Direct Approach to Polysubstituted Pyrroles was written by Zhu, Lei;Yu, Yinghua;Mao, Zhifeng;Huang, Xueliang. And the article was included in Organic Letters in 2015.Category: oxazolidine This article mentions the following:

An effective gold-catalyzed intermol. nitrene transfer by the reaction of 2H-azirines and ynamides is reported, which provides highly substituted pyrroles in a straightforward manner. This transformation proceeds under mild conditions and gives the polysubstituted pyrroles in good-to-excellent yields. Preliminary results indicate that a nongold carbenoid pathway is preferred for current pyrrole synthesis. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Category: oxazolidine).

3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Some reports highlighted again the effectiveness of oxazolidine-based compounds in driving the stereo- or diastereotopic outcome of chemical reactions.Category: oxazolidine

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Gold-catalyzed intermolecular cyclocarboamination of ynamides with 1,3,5-triazinanes: en route to tetrahydropyrimidines was written by Zeng, Zhongyi;Jin, Hongming;Song, Xinlong;Wang, Qian;Rudolph, Matthias;Rominger, Frank;Hashmi, A. Stephen K.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.Computed Properties of C11H9NO2 This article mentions the following:

Gold-catalyzed regioselective cyclocarboamination of ynamides R¹CCR² [R¹ = 4-methoxyphenyl, 3-chlorophenyl, 6-methoxynaphth-2-yl, etc. R² = methyl(2,4,6-trimethylphenyl)aminyl, 2-oxo-1,3-oxazolidin-3-yl, 3-acetyl-1H-indol-1-yl, etc.] with 1,3,5-triazinanes I (Ar = Ph, 2-fluorophenyl, 3-methyl-4-chlorophenyl, etc.) opens a facile and modular access to valuable 5-aminotetrahydropyrimidines II in good to excellent yields. The aminotetrahydropyrimidines constitutes an unprecedented yet challenging annulation of ynamides with unstrained saturated heterocycles. This new protocol is distinguished by easy operation, readily available starting materials, stable four-atom building units, good functional-group compatibility and scaling-up potential. The preliminary mechanistic studies indicate that the present intermol. cyclocarboamination arises from a pseudo-three-component [2+2+2] cycloaddition In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Computed Properties of C11H9NO2).

3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Computed Properties of C11H9NO2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Palladium catalyzed oxidation of ynamides using dimethyl sulfoxide as oxidant: a facile way to synthesize α-ketoamide derivatives was written by Meng, Tuanjie;Feng, Cuilan;Liu, Lantao;Wang, Tao;Xu, Kai;Zhao, Wenxian. And the article was included in Youji Huaxue in 2016.Application of 888329-88-2 This article mentions the following:

A series of α-ketoamide derivatives were obtained from the palladium catalyzed oxidation of ynamides using cheap and readily available DMSO as oxidant and solvent under room temperature The structures of all products were characterized by ¹H NMR, ¹³C NMR, IR and HRMS. This protocol has some distinct advantages of mild conditions, simple work-up, readily available starting materials and fast reaction rate. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Application of 888329-88-2).

3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Application of 888329-88-2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Copper-Mediated Selective Cross-Coupling of 1,1-Dibromo-1-alkenes and Heteronucleophiles: Development of General Routes to Heterosubstituted Alkynes and Alkenes was written by Jouvin, Kevin;Coste, Alexis;Bayle, Alexandre;Legrand, Frederic;Karthikeyan, Ganesan;Tadiparthi, Krishnaji;Evano, Gwilherm. And the article was included in Organometallics in 2012.Name: 3-(Phenylethynyl)oxazolidin-2-one This article mentions the following:

Efficient and general procedures for the cross-coupling of 1,1-dibromoalkenes and N-, O-, and P-nucleophiles are reported. Fine-tuning of the reaction conditions allows for either site-selective, double, or alkynylative cross-coupling, therefore providing divergent and straightforward entries to numerous building blocks such as bromoenamides, ynamides, ketene N,N-acetals, bromoenol ethers, ynol ethers, ketene O,O-acetals, or vinylphosphonates and further expanding the copper catalysis toolbox with useful and versatile processes. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Name: 3-(Phenylethynyl)oxazolidin-2-one).

3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. A common way to produce multisubstituted oxazolidines is by means of cycloaddition reactions. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries.Name: 3-(Phenylethynyl)oxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Synthesis of Z-Enamides through Heterogeneous Gold-Catalyzed Stereoselective Hydrogenation of Ynamides was written by Lin, Long;Zeng, Xiaojun;Xu, Bo. And the article was included in Journal of Organic Chemistry in 2019.Related Products of 888329-88-2 This article mentions the following:

A facile synthesis of Z-enamides via heterogeneous Au/TiO₂ catalyzed stereoselective hydrogenation of ynamides has been developed. Easy to handle and inexpensive ammonium formate was used as the hydrogen source, and Z-enamides were formed in a highly stereoselective manner. The com. available gold nanoparticle catalyst could be recycled multiple times without a significant loss of activity. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Related Products of 888329-88-2).

3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries. Chiral oxazolidines are widely used as chiral auxiliaries, chiral ligands, protecting and/or directing groups in a variety of asymmetric transformations, thanks also to their easy cleavage or their further elaboration possibilities.Related Products of 888329-88-2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Synthesis of δ- and α-carbolines via nickel-catalyzed [2+2+2] cycloaddition of functionalized alkyne-nitriles with alkynes was written by Wang, Gaonan;You, Xu;Gan, Yi;Liu, Yuanhong. And the article was included in Organic Letters in 2017.Related Products of 888329-88-2 This article mentions the following:

A new method for the synthesis of δ- and α-carbolines I, II, resp., through Ni-catalyzed [2+2+2] cycloaddition of ynamide-nitriles 2-R¹CCNTsC₆H₄CN (1) or alkyne-cyanamides 2-(R¹CC)C₆H₄N(Ts)CN (3) with alkynes R²CCR³ has been developed. The catalytic system of NiCl₂(DME)/dppp/Zn with a low-cost Ni(II)-precursor was first utilized in Ni-catalyzed [2+2+2] cycloaddition reactions, and the in situ generated Lewis acid may play an important role for the successful transformation. Not only internal alkynes but also terminal alkynes undergo the desired cycloaddition reactions efficiently to furnish the carboline derivatives with wide diversity and functional group tolerance. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Related Products of 888329-88-2).

3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Related Products of 888329-88-2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Metal-free intermolecular formal cycloadditions enable an orthogonal access to nitrogen heterocycles was written by Xie, Lan-Gui;Niyomchon, Supaporn;Mota, Antonio J.;Gonzalez, Leticia;Maulide, Nuno. And the article was included in Nature Communications in 2016.COA of Formula: C11H9NO2 This article mentions the following:

A family of metal-free intermol. formal cycloaddition reactions that enable highly selective and orthogonal access to isoquinolines, e.g., I and pyrimidines II (R = CH₃, 4-FC₆H₄, H₂CC₆H₅, etc.; R¹ = CH₃, 4-FC₆H₄, cyclohexyl, etc.; R² = heptyl, cyclopropyl, 4-chlorophenyl, etc.; R³ = SMe, 2-oxo-1,3-oxazolidin-3-yl) has been described. Applications of the products are complemented by a d. functional theory mechanistic anal. that pinpoints the crucial factors responsible for the selectivity observed, including stoichiometry and the nature of the heteroalkyne. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2COA of Formula: C11H9NO2).

3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.COA of Formula: C11H9NO2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Stereoselective Synthesis of Pyrido- and Pyrrolo[1,2-c][1,3]oxazin-1-ones via a Nucleophilic Addition-Cyclization Process of N,O-Acetal with Ynamides was written by Han, Pan;Mao, Zhuo-Ya;Si, Chang-Mei;Zhou, Zhu;Wei, Bang-Guo;Lin, Guo-Qiang. And the article was included in Journal of Organic Chemistry in 2019.SDS of cas: 888329-88-2 This article mentions the following:

In the presence of BF₃·Et₂O, nonracemic aminals such as I (TBDMS = t-BuMe₂Si) underwent diastereoselective addition and cyclization reactions with ynamides such as PhCCNTsBn (Ts = 4-MeC₆H₄SO₂; Bn = PhCH₂) to yield pyrrolooxazinones and pyridooxazinones such as II in >99:1 dr (for arylalkynylamines) and in 75:25 dr (for an ethynylamine). Nonracemic alkynyloxazolidinones underwent addition and cyclization reactions with racemic pyrrolidine and piperidine aminals to yield nonracemic pyrrolooxazinones and pyridooxazinones in 71:29-75:25 dr. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2SDS of cas: 888329-88-2).

3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. A common way to produce multisubstituted oxazolidines is by means of cycloaddition reactions. In another report, the incorporation of an additional substituted oxazolidine ring over a range of new biphenylazepinium salt organocatalysts for the asymmetric epoxidation of alkenes improved enantiocontrol over the parent structures.SDS of cas: 888329-88-2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Metal-Free Synthesis of Highly Substituted Pyridines by Formal [2+2+2] Cycloaddition under Mild Conditions was written by Xie, Lan-Gui;Shaaban, Saad;Chen, Xiangyu;Maulide, Nuno. And the article was included in Angewandte Chemie, International Edition in 2016.Recommanded Product: 3-(Phenylethynyl)oxazolidin-2-one This article mentions the following:

The synthesis of pyridines through direct intermol. cycloaddition of alkynes and nitriles is a contemporary challenge in organic synthesis. A Bronsted acid mediated formal [2+2+2] cycloaddition of heteroalkynes and nitriles was developed that proceeds under mild conditions. This constitutes a modular approach to highly substituted pyridine cores. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Recommanded Product: 3-(Phenylethynyl)oxazolidin-2-one).

3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidine-based compounds are well-known chiral auxiliaries and strategic molecular moieties in chemistry since they can effectively mask or mimic amino acid units or amino alcohols. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol. Oxazolidines are weaker bases (pKa 6–7) than parent β-amino alcohols and found to be more lipophilic than the parent compound at physiological pH.Recommanded Product: 3-(Phenylethynyl)oxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Unusual mechanisms in Claisen rearrangements: an ionic fragmentation leading to a meta-selective rearrangement was written by Maryasin, Boris;Kaldre, Dainis;Galaverna, Renan;Klose, Immo;Ruider, Stefan;Drescher, Martina;Kaehlig, Hanspeter;Gonzalez, Leticia;Eberlin, Marcos N.;Jurberg, Igor D.;Maulide, Nuno. And the article was included in Chemical Science in 2018.Reference of 888329-88-2 This article mentions the following:

A mechanistic investigation of the acid-catalyzed redox-neutral oxoarylation reaction of ynamides using electrospray ionization mass-spectrometry (ESI-MS) and quantum chem. calculations (DFT and MP2) is presented. This study reveals the diversity of pathways and products available from an otherwise deceptively simple-looking, classical transformation: fragmentation, an unusual meta-arylation and competing α-carbonyl cation pathways are some of the alternatives unveiled by ESI-MS and mechanistic experiments Detailed calculations explain the observed trends and rationalize the results. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Reference of 888329-88-2).

3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries.Reference of 888329-88-2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem