Tag: 185.2203

Lithium Amino Alkoxide-Evans Enolate Mixed Aggregates: Aldol Addition with Matched and Mismatched Stereocontrol was written by Jermaks, Janis;Tallmadge, Evan H.;Keresztes, Ivan;Collum, David B.. And the article was included in Journal of the American Chemical Society in 2018.Computed Properties of C9H15NO3 This article mentions the following:

Building on structural and mechanistic studies of lithiated enolates derived from acylated oxazolidinones (Evans enolates) and chiral lithiated amino alkoxides, we found that amino alkoxides amplify the enantioselectivity of aldol additions The pairing of enantiomeric series affords matched and mismatched stereoselectivities. The structures of mixed tetramers showing 2:2 and 3:1 (alkoxide-rich) stoichiometries are determined spectroscopically. Rate and computational studies provide a viable mechanistic and stereochem. model based on the direct reaction of the 3:1 mixed tetramers, but they raise unanswered questions for the 2:2 mixed aggregates. In the experiment, the researchers used many compounds, for example, (R)-4-Isopropyl-3-propionyloxazolidin-2-one (cas: 89028-40-0Computed Properties of C9H15NO3).

(R)-4-Isopropyl-3-propionyloxazolidin-2-one (cas: 89028-40-0) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Computed Properties of C9H15NO3

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Synthesis of a Common Cyclopentanoid Building Block for the Total Synthesis of Jatropha-5,12- and -6(17),11-dienes by Uncatalyzed Intramolecular Carbonyl Ene (ICE) Reaction was written by Butt, Lena;Hiersemann, Martin. And the article was included in Synthesis in 2014.SDS of cas: 89028-40-0 This article mentions the following:

The authors report a scalable synthesis of a common cyclopentanoid building block for 15-hydroxyjatropha-5,12-diene and 15-hydroxyjatropha-6(17),11-diene in eleven steps. A key to the synthesis is an uncatalyzed intramol. carbonyl-ene (ICE) reaction of an ε,ζ-unsaturated α-keto ester. The synthesis of the target compound was achieved using (4R)-4-(1-methylethyl)-3-(1-oxopropyl)-2-oxazolidinone as a chiral auxiliary. The title compound thus formed was a cyclopentanoid intermediate for 3a-(acetyloxy)-1-(benzoyloxy)-2,3,3a,7,8,10,11,13a-octahydro-7,11-dihydroxy-2,5,8,8,12-pentamethyl-1H-cyclopentacyclododecene-4,9-dione [euphoheliosnoid D]. In the experiment, the researchers used many compounds, for example, (R)-4-Isopropyl-3-propionyloxazolidin-2-one (cas: 89028-40-0SDS of cas: 89028-40-0).

(R)-4-Isopropyl-3-propionyloxazolidin-2-one (cas: 89028-40-0) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.SDS of cas: 89028-40-0

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Syntheses of cystothiazole A and its stereoisomers: importance of stereochemistry for antifungal activity was written by Ojika, Makoto;Watanabe, Tatsuya;Qi, Jianhua;Tanino, Tomoharu;Sakagami, Youji. And the article was included in Tetrahedron in 2004.Safety of (R)-4-Isopropyl-3-propionyloxazolidin-2-one This article mentions the following:

The enantiocontrolled total syntheses of all the stereoisomers of a myxobacterial antibiotic, cystothiazole A (I), are described. The natural syn stereochem. at the C4-C5 position was controlled by the asym. Evans aldol process, whereas the anti relationship was introduced by a modified Evans aldol methodol. Starting with a known aldehyde, the common substrate of the aldol reactions, cystothiazole A and its three stereoisomers were synthesized in 9 steps. All three stereoisomers did not show antifungal activity even at a dosage 2500-fold that of cystothiazole A. In the experiment, the researchers used many compounds, for example, (R)-4-Isopropyl-3-propionyloxazolidin-2-one (cas: 89028-40-0Safety of (R)-4-Isopropyl-3-propionyloxazolidin-2-one).

(R)-4-Isopropyl-3-propionyloxazolidin-2-one (cas: 89028-40-0) belongs to oxazolidine derivatives. A common way to produce multisubstituted oxazolidines is by means of cycloaddition reactions. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Safety of (R)-4-Isopropyl-3-propionyloxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem