Tag: 184363-66-4

184363-66-4, (S)-4-Phenyl-3-propionyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To the reaction flask was added 150 mL of a 1 M solution of LiHMDS (lithium bis(trimethylsilyl)amide) in tetrahydrofuran. Cool to -50 C. Slowly drip the tetrahydrofuran containing 32.8 g (0.15 mol, 1.1 eq) of (S)-4-phenyl-3-propionyloxazolidinone(60mL) solution,The mixture was further stirred at -50 C for 80 minutes.Dropping 50 g (0.134 mol, 1.0 eq) containing compound IIb Anhydrous tetrahydrofuran (100 mL) solution,Continue to incubate for 30 minutes after the dropwise addition.Slowly warm to room temperature and stir. Complete to the substrateConversion.Wash the organic layer with saturated ammonium chloride solution (100ml), water (100ml), saturated brine (100ml), separate, organicThe layer was dried over anhydrous MgSO4 and evaporated.53.2 g of crude compound IIIb were obtained, The yield was 87.3%., 184363-66-4

The synthetic route of 184363-66-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shanghai Disainuo Chemical Pharmaceutical Co., Ltd.; Yancheng Disainuo Pharmaceutical Co., Ltd.; Jiangsu Puxin Pharmaceutical Co., Ltd.; Shanghai Disainuo Pharmaceutical Co., Ltd.; Li Jinliang; Zhao Nan; Lou Yanpeng; (12 pag.)CN109206419; (2019); A;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184363-66-4,(S)-4-Phenyl-3-propionyloxazolidin-2-one,as a common compound, the synthetic route is as follows.

(S) -4-benzyl-3-propionyloxazolidinone (16.5 g, 1.1 eq)Was dissolved in 40 ml of dichloromethane, cooled to 0 C,A solution of titanium tetrachloride (14 g, 1.1 eq) in dichloromethane was added dropwise,After the drop, keep stirring below 0 C for 10 min.Diisopropylethylamine (9.7 g, 1.1 eq) was added dropwise,After the drop, keep stirring below 0 C for 30 min. The compound (II-b) (30 g, 1 equiv)Dissolved in methylene chloride, added dropwise to the reaction system,After the dropwise addition, the mixture was stirred at 20 to 25 C for 10 hours.To the reaction system, an aqueous solution of saturated ammonium chloride was added,Extracted with dichloromethane, and the resulting organic phases were washed with water and water, respectivelyWashed with saturated brine and dried over anhydrous sodium sulfate.The solvent was removed by evaporation under reduced pressure to give the crude product. The crude product was purified by column chromatography,To give the title compound (IV-a) (33.9 g, yield 91%).HPLC detection, no enantiomeric detection, that is, chiral purity of 100%.

The synthetic route of 184363-66-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Zhejiang Yongning Pharmaceutical Co., Ltd.; Ye Tianjian; Lu Xiuwei; Yu Guangliang; Liu Ting; (14 pag.)CN105085322; (2017); B;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem