The synthetic route of 16251-45-9 has been constantly updated, and we look forward to future research findings.
With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16251-45-9,(4S,5R)-4-Methyl-5-phenyloxazolidin-2-one,as a common compound, the synthetic route is as follows.
Example 32e (4S,5R)-3-(Bromoacetyl)-4-methyl-5-phenyloxazolidin-2-one 82 ml of a 2.5 molar solution of butyllithium in hexane is added to a solution of 33.06 g (186.6 mmol) of (4S,5R)-4-methyl-5-phenyloxazolidin-2-one in 500 ml of tetrahydrofuran within 30 minutes at -70 C. under argon. Then, a solution of 15.55 ml (187 mmol) of bromoacetyl chloride in 250 ml of tetrahydrofuran is added in drops in such a way that the internal temperature does not exceed -65 C. Then, it is stirred for one more hour at -70 C. Then, the reaction mixture is poured onto 50 ml of saturated aqueous ammonium chloride solution. 90 ml of saturated aqueous sodium bicarbonate solution is then added, allowed to come to 25 C., diluted with water and extracted with ethyl acetate. The organic phase is washed with saturated aqueous sodium chloride solution, dried on sodium sulfate and chromatographed on silica gel. 42.32 g (76%) of the title compound is obtained. 1H-NMR (CDCl3): delta=0.95 (3H), 4.57 (2H), 4.80 (1H), 5.76 (1H), 7.2-7.5 (5H) ppm.
The synthetic route of 16251-45-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; KLAR, ULRICH; SCHWEDE, WOLFGANG; SKUBALLA, WERNER; BUCHMANN, BERND; US2003/144523; (2003); A1;,
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