Tag: 160695-26-1

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.160695-26-1,(R)-4-Phenyl-3-propionyloxazolidin-2-one,as a common compound, the synthetic route is as follows.

Example-21: Preparation of (R)-3-((S)-2-methylpent-4-enoyl)-4-phenyloxazolidin-2-one (Formula B-II) A solution of (R)-4-phenyl-3-propionyloxazolidin-2-one compound of formula B-I (100 gm) in tetrahydrofuran (500 ml) was slowly added to a pre-cooled mixture of sodium bis(trimethylsilyl)amide (240 ml) in tetrahydrofuran (500 ml) at -70C to -75C under N2 atmosphere and stirred for 1 hr at the same temperature. Allyl bromide (60 ml) was slowly added to the reaction mixture at -70C to -75C and stirred for 1 hr at the same temperature. Raised the temperature of the reaction mixture to 0-5C and stirred for 1 hr at the same temperature. Aqueous ammonium chloride solution followed by methyl tert.butyl ether were added to the reaction mixture at 0-5C. Raised the temperature of the reaction mixture to 25- 30C and stirred for 15 min at the same temperature. Both the organic and aqueous layers were separated and washed the organic layer with aqueous sodium chloride solution. Distilled off the solvent completely from the organic layer under reduced pressure and co- distilled with isopropyl alcohol. 300 ml of isopropyl alcohol was added to the obtained compound. Heated the reaction mixture to 60-65 C and stirred for 15 min at the same temperature. Cooled the reaction mixture to 0-5C. Petroleum ether (300 ml) was slowly added to the precipitated solid at 0-5 C and stirred for 60 min at the same temperature. Filtered the solid, washed with petroleum ether and dried to get the title compound. Yield: 65.0 gm; M.R: 68-70C.

As the paragraph descriping shows that 160695-26-1 is playing an increasingly important role.

Reference£º
Patent; MSN LABORATORIES PRIVATE LIMITED; THIRUMALAI RAJAN, Srinivasan; ESWARAIAH, Sajja; VENKAT REDDY, Ghojala; WO2015/87351; (2015); A2;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

160695-26-1, (R)-4-Phenyl-3-propionyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 16a (22.4 g, 96.0 mmol) in THF (300 mL) cooled to -78 C was added NaHMDS (100 mL, 100 mmol, 1.0 M solution in THF) dropwise over 20 min. The reaction was stirred at -78 C for an additional hour before the dropwise addition of allyl iodide (8.78 mL, 96.0 mmol) over 10 min. The reaction was stirred for an additional 5 hr at -78 C before the cooling bath was removed and the reaction was quenched with the addition of sat. NH4Cl. The layers were separated, and the aqueous layer was washed with Et2O x 3. The combined organic material was washed with sat. Na2S2O3, dried over MgSO4, filtered, concentrated, and purified via flash chromatography (Teledyne ISCO flash chromatography system; silica gel column; 9:1Hexane:EtOAc) to afford the desired product as a colorless oil (14.9 g, 58% yield). Spectral data were in accordance with reported literature values.5

As the paragraph descriping shows that 160695-26-1 is playing an increasingly important role.

Reference£º
Article; Reed, Carson W.; Fulton, Mark G.; Nance, Kellie D.; Lindsley, Craig W.; Tetrahedron Letters; vol. 60; 10; (2019); p. 743 – 745;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem