Tag: 115.1305

N-acyl-5,5-dimethyl-oxazolidin-2-ones as latent aldehyde equivalents was written by Bach, Jordi;Bull, Steven D.;Davies, Stephen G.;Nicholson, Rebecca L.;Sanganee, Hitesh J.;Smith, Andrew D.. And the article was included in Tetrahedron Letters in 1999.Formula: C5H9NO2 This article mentions the following:

N-acyl-5,5-dimethyl-oxazolidin-2-ones can function as versatile latent aldehyde equivalent Reductive cleavage with DIBAL-H affords aldehydes in good yield, while tandem DIBAL-H/Wittig methodol. affords α,β-unsaturated esters. In the experiment, the researchers used many compounds, for example, 5,5-Dimethyloxazolidin-2-one (cas: 1121-83-1Formula: C5H9NO2).

5,5-Dimethyloxazolidin-2-one (cas: 1121-83-1) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Some reports highlighted again the effectiveness of oxazolidine-based compounds in driving the stereo- or diastereotopic outcome of chemical reactions.Formula: C5H9NO2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Design, synthesis and application of a new type of bifunctional Le-Phos in highly enantioselective γ-addition reactions of N-centered nucleophiles to allenoates was written by Qiu, Haile;Chen, Xiaofeng;Zhang, Junliang. And the article was included in Chemical Science in 2019.Recommanded Product: 5,5-Dimethyloxazolidin-2-one This article mentions the following:

A novel class of cyclic phosphine derived bifunctional catalysts (R_P,S,S,R_S)/(S_P,R,S,R_S)-Le-Phos I (R = Ph, pentafluorophenyl, cyclopentyl, etc.) is reported, which can be readily prepared from inexpensive and com. available starting materials and exhibit good performances in enantioselective γ-addition reactions of N-centered nucleophiles e.g., 1,3-oxazolidin-2-one and allenoates R¹CH=C=CHC(O)OR² (R¹ = Me, Et, cyclopentyl, etc.; R² = Et, tert-Bu, 4-fluorophenyl, etc.) under mild conditions. The salient features of this reaction include high product yields, good enantioselectivity, mild reaction conditions, and broad substrate scope and gram-scale scalability. In the experiment, the researchers used many compounds, for example, 5,5-Dimethyloxazolidin-2-one (cas: 1121-83-1Recommanded Product: 5,5-Dimethyloxazolidin-2-one).

5,5-Dimethyloxazolidin-2-one (cas: 1121-83-1) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries.Recommanded Product: 5,5-Dimethyloxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Synthesis of oxazolidin-2-ones and imidazolidin-2-ones directly from 1,3-diols or 3-amino alcohols using iodobenzene dichloride and sodium azide was written by He, Tian;Gao, Wen-Chao;Wang, Wei-Kun;Zhang, Chi. And the article was included in Advanced Synthesis & Catalysis in 2014.Recommanded Product: 1121-83-1 This article mentions the following:

A general and efficient method for the synthesis of oxazolidin-2-ones and imidazolidin-2-ones directly from 1,3-diols and 3-amino alcs. was developed using the same reagent combination of PhICl₂ and NaN₃. In the experiment, the researchers used many compounds, for example, 5,5-Dimethyloxazolidin-2-one (cas: 1121-83-1Recommanded Product: 1121-83-1).

5,5-Dimethyloxazolidin-2-one (cas: 1121-83-1) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Recommanded Product: 1121-83-1

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Asymmetric synthesis of β-amino-γ-substituted-γ-butyrolactones: Double diastereoselective conjugate addition of homochiral lithium amides to homochiral α,β-unsaturated esters was written by Cailleau, Thais;Cooke, Jason W. B.;Davies, Stephen G.;Ling, Kenneth B.;Naylor, Alan;Nicholson, Rebecca L.;Price, Paul D.;Roberts, Paul M.;Russell, Angela J.;Smith, Andrew D.;Thomson, James E.. And the article was included in Organic & Biomolecular Chemistry in 2007.Quality Control of 5,5-Dimethyloxazolidin-2-one This article mentions the following:

Nonracemic α,β-unsaturated esters such as I (R = Me, Ph; TBS = tert-butyldimethylsilyl) containing a single, γ-stereogenic center undergo stereoselective addition of lithium amides derived from nonracemic benzylamines (with or without concomitant alkylation reactions) to give β-amino esters such as (benzylamino)pentanoates II (R = Me, Ph; R¹ = H, Me). The stereoisomers produced by the additions of lithium N-(α-methylbenzyl)-N-benzylamides to nonracemic γ-substituted-α,β-unsaturated esters such as I are determined by the configurations of the amides, while the relative stereochem. of the ester and the amide determines the level of stereoselectivity observed The stereoselectivities of the additions of lithium N-(α-methylbenzyl)-N-benzylamides to a nonracemic γ-substituted-α,β-unsaturated enoyl oxazolidinone is opposite to those observed in the additions of lithium N-(α-methylbenzyl)-N-benzylamides to nonracemic γ-substituted-α,β-unsaturated esters with the same configurations at the γ stereocenter. Desilylation and cyclization (with or without epimerization) of the resultant β-amino carbonyl compounds provides nonracemic β-amino-γ-lactones such as III (R = Me, Ph; R¹ = H, Me) with good yields and high diastereoselectivities. In the experiment, the researchers used many compounds, for example, 5,5-Dimethyloxazolidin-2-one (cas: 1121-83-1Quality Control of 5,5-Dimethyloxazolidin-2-one).

5,5-Dimethyloxazolidin-2-one (cas: 1121-83-1) belongs to oxazolidine derivatives. A common way to produce multisubstituted oxazolidines is by means of cycloaddition reactions. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Quality Control of 5,5-Dimethyloxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem