Tag: 100-200

On October 31, 2014, Valeev, R. F.; Bikzhanov, R. F.; Miftakhov, M. S. published an article.Safety of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one The title of the article was Building blocks for (C15-C3)-modified epothilone D analogs. And the article contained the following:

A promising potentially biol. active structure have been designed by isosteric rearrangement of the C15-C3 fragment of epothilone D, and building blocks, e.g., I, necessary for its assembly have been synthesized. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Safety of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

The Article related to epothilone d building block preparation, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.Safety of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On April 18, 2006, Kamal, Ahmed; Khanna, G. B. Ramesh; Krishnaji, T.; Ramu, R. published an article.Name: (R)-5-(Hydroxymethyl)oxazolidin-2-one The title of the article was Lipase-mediated resolution of 3-hydroxy-4-trityloxybutanenitrile: synthesis of 2-amino alcohols, oxazolidinones and GABOB. And the article contained the following:

Lipase-mediated kinetic resolution of 3-hydroxy-4-trityloxybutanenitrile gave the (S)-alc. and (R)-acetate in good yields and high enantioselectivities. The resolution using Pseudomonas cepacia lipase (Burkholderia cepacia) immobilized on modified ceramic particles (PS-C) in diisopropyl ether gave the best results. The use of base additives in this transesterification drastically reduces the reaction time without effecting the yields or enantioselectivities. Resolved 3-hydroxy-4-trityloxybutanenitrile has been utilized for the synthesis of enantiomerically pure 5-tosyloxymethyl-1,3-oxazolidine-2-one, which is an important intermediate for the preparation of β-adrenergic blocking agents and oxazolidinone based antimicrobial agents. Enantiomerically pure (R)-3-hydroxy-4-trityloxybutanenitrile and (S)-5-tosyloxymethyl-1,3-oxazolidine-2-one have been utilized in the enantioconvergent synthesis of (R)-GABOB. The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).Name: (R)-5-(Hydroxymethyl)oxazolidin-2-one

The Article related to lipase kinetic resolution hydroxytrityloxybutanenitrile, Fermentation and Bioindustrial Chemistry: Pharmaceuticals (Including Nutrients) and other aspects.Name: (R)-5-(Hydroxymethyl)oxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On August 22, 2002, Wiedeman, Paul E.; Djuric, Steven W.; Pilushchev, Marina; Sciotti, Richard J.; Madar, David J.; Kopecka, Hana published a patent.Name: (R)-5-(Hydroxymethyl)oxazolidin-2-one The title of the patent was Preparation of oxazolidinones as antibacterial agents. And the patent contained the following:

Title compounds [I; A = Ph, substituted 5-membered aromatic ring containing 1-2 N, O, S, or 6-membered aryl containing 1-2 N atoms; R1, R2 = H, alkyl, alkoxy, thioalkoxy, cycloalkyl, OH, amino, aminoalkyl, halo, haloalkyl, perfluoroalkyl; R3, R4, R5 = H, carboxamido, cyano, halo, NO2, perfluoroalkyl, (substituted) alkyl, alkanoyl, cycloalkyl, cyclothioalkoxy, cycloalkylsulfinyl, cycloalkoxycarbonyl, thioalkoxy, alkylsulfinyl, alkylsulfonyl, alkoxycarbonyl, cycloalkenyl, thiocycloalkenyloxy, cycloalkenylsulfinyl, cycloalkenylsulfonyl, aryl, aralkyl, arylthio, arylsulfinyl, arylsulfonyl, aryloxycarbonyl, heteroaryl, heteroarylalkyl, etc.; R6 = NHR7, N-phthalimido, NR7R8, NR8CO2R9, NR8CON(R8)2, OR9, SR9, SOR9, SO2R9; R7 = (substituted) alkanoyl, aryloyl, thioalkanoyl, heteroaryl, heteroarylalkyl, heterocycle, heterocyclylalkyl, etc.; R8 = H, (substituted) alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, heteroarylalkyl, heterocycle, heterocyclylalkyl, protecting group; R9 = (substituted) alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, heteroarylalkyl, heterocycle, etc.] were prepared as antibacterial agents. N-[[(5S)-3-[4-(2,2-dibromovinyl)-3-fluorophenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide, 5-acetyl-2-thienylboronic acid, tris(dibenzylideneacetone)dipalladium, and aqueous Na2CO3 in deoxygenated dimethoxyethane were heated at 55° for 20 h to give N-[[(5S)-3-[4-[(Z)-2-(5-acetyl-2-thienyl)-2-bromoethenyl]-3-fluorophenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide. In an antibacterial activity assay, I inhibited the growth of Staphylococcus aureus, Staphylococcus epidermidis, Moraxella catarrhalis, Enterococcus faecium, and Streptococcus pneumoniae with MIC’s in the range of about 0.125 μg/mL to about 128 μg/mL. I are also useful for treating psoriasis, arthritis, and toxicity due to chemotherapy (no data). The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).Name: (R)-5-(Hydroxymethyl)oxazolidin-2-one

The Article related to oxazolidinone preparation bacterial infection psoriasis arthritis chemotherapy toxicity treatment, thienyl oxazolidinylmethyl acetamide preparation antibacterial, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Name: (R)-5-(Hydroxymethyl)oxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On May 10, 2017, Li, Siyuan; Gui, Shaoxiao; Zhang, Jicheng; Huang, Luning; Tao, Anping; Gu, Hong published a patent.Formula: C4H7NO3 The title of the patent was Preparation method for tedizolid and its intermediate. And the patent contained the following:

The invention relates to a preparation method for a tedizolid compound in Formula I. In Formula I, R is selected from hydrogen, benzyl or benzyl substituted by a substituent, the substituent is selected from a group consisting of halogen, nitryl, C1-C6 alkyl, and C1-C6 alkoxy, and R1 is C1-C6 alkyl or C1-C6 alkyl substituted by halogen. The method comprises: generating a compound having a structure with formula II and a compound having a structure with formula III by a coupled reaction under the catalysis of a metal catalyst, a substituent of R being defined as above, where X is a leaving group, the leaving group comprising chlorine, bromine, iodine, sulfonyl oxy such as trifluoromethane sulfonic oxy, methylsulfonyl oxy and benzenesulfonyl oxy, or benzenesulfonyl oxy substituted by one or more substituents, the substituent being selected from a group consisting of halogen, C1-C6 alkyl, and C1-C6 alkoxy. The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).Formula: C4H7NO3

The Article related to tedizolid preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Formula: C4H7NO3

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On May 11, 2017, Li, Siyuan; Gui, Shaoxiao; Zhang, Jicheng; Huang, Luning; Tao, Anping; Gu, Hong published a patent.Computed Properties of 97859-49-9 The title of the patent was Preparation method for tedizolid and its intermediate. And the patent contained the following:

The present invention relates to a preparation method for a tedizolid compound in Formula I. In Formula I, R is selected from hydrogen, benzyl or benzyl substituted by a substituent, the substituent is selected from a group consisting of halogen, nitryl, C1-C6 alkyl, and C1-C6 alkoxy, and R1 is C1-C6 alkyl or C1-C6 alkyl substituted by halogen. The method comprises: generating a compound having a structure with formula II and a compound having a structure with formula III by a coupled reaction under the catalysis of a metal catalyst, a substituent of R being defined as above, where X is a leaving group, the leaving group comprising chlorine, bromine, iodine, sulfonyl oxy such as trifluoromethane sulfonic oxy, methylsulfonyl oxy and benzenesulfonyl oxy, or benzenesulfonyl oxy substituted by one or more substituents, the substituent being selected from a group consisting of halogen, C1-C6 alkyl, and C1-C6 alkoxy. The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).Computed Properties of 97859-49-9

The Article related to tedizolid preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Computed Properties of 97859-49-9

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On November 30, 2009, Concellon, Carmen; Duguet, Nicolas; Smith, Andrew D. published an article.Reference of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one The title of the article was N-Heterocyclic Carbene-Mediated Enantioselective Addition of Phenols to Unsymmetrical Alkylarylketenes. And the article contained the following:

Chiral N-heterocyclic carbenes (NHCs) mediate the enantioselective addition of 2-phenylphenol to unsym. alkylarylketenes, delivering α-alkyl-α-arylacetic acid derivatives with good levels of enantiocontrol (up to 84% ee). Enantiodivergent stereochem. outcomes are observed using 2-phenylphenol and benzhydrol in the NHC-promoted esterification reaction using a triazolium precatalyst derived from pyroglutamic acid, consistent with distinct mechanistic pathways operating within these processes. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Reference of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

The Article related to addition stereoselective phenol alkylarylketene n heterocyclic carbene catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Esters, Acyl Peroxides, Acyl Halides and other aspects.Reference of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On May 19, 2017, Abas, Hossay; Linsdall, Sean M.; Mamboury, Mathias; Rzepa, Henry S.; Spivey, Alan C. published an article.SDS of cas: 168297-86-7 The title of the article was Total Synthesis of (+)-Lophirone H and Its Pentamethyl Ether Utilizing an Oxonium-Prins Cyclization. And the article contained the following:

The first total synthesis of (+)-lophirone H (I) and its pentamethyl ether, featuring an oxonium-Prins cyclization/benzylic cation trapping reaction, is described. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).SDS of cas: 168297-86-7

The Article related to lophirone h stereoselective synthesis oxonium prins cyclization, Biomolecules and Their Synthetic Analogs: Flavonoids and Natural and Fused Coumarins and other aspects.SDS of cas: 168297-86-7

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On June 15, 2018, Peer Mohamed, Shahul Hameed; Bharatham, Nagakumar; Katagihallimath, Nainesh; Sharma, Sreevalli; Nandishaiah, Radha; Ramachandran, Vasanthi published a patent.COA of Formula: C4H7NO3 The title of the patent was Preparation of heterocyclic derivatives for use as antibacterial agents. And the patent contained the following:

Title compounds I [R1 = (un)substituted alkyl, alkenyl, cycloalkyl, etc.; R2 and R3 independently = H, F, OH, alkyl, etc.; R8 = H, F, or alkyl; R9 = H, F, CN, OH, or alkyl; L = N, CH, CCN, C-halo, etc.; M = CH or alkyl; each X and Y independently = N, CH, CCN, etc.; Z = O, S, or CH2; m = 0 or 1; n = 0 to 2; with provisions], and their stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivatives thereof, are prepared and disclosed as antibacterial agents. Thus, e.g., II was prepared by a multistep procedure (preparation given). I were evaluated in S. aureus (ATCC 29213) antibacterial activity assays, e.g., II demonstrated a <4 μg/mL min. inhibitory concentration in LB media. The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).COA of Formula: C4H7NO3

The Article related to heterocyclic preparation antibacterial agent, pyridooxazinone preparation antibacterial agent, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.COA of Formula: C4H7NO3

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On December 13, 2018, Peer Mohamed, Shahul Hameed; Bharatham, Nagakumar; Katagihallimath, Nainesh; Sharma, Sreevalli; Nandishaiah, Radha; Ramachandran, Vasanthi; Venkataraman, Balasubramanian published a patent.Product Details of 97859-49-9 The title of the patent was Preparation of heterocyclic derivatives for use as antibacterial agents. And the patent contained the following:

Title compounds I [R1 = (un)substituted alkyl, alkenyl, cycloalkyl, etc.; R2 and R3 independently = H, F, OH, alkyl, etc.; R8 = H, F, or alkyl; R9 = H, F, CN, OH, or alkyl; L = N, CH, CCN, C-halo, etc.; M = CH or alkyl; each X and Y independently = N, CH, CCN, etc.; Z = O, S, or CH2; m = 0 or 1; n = 0 to 2; with provisions], and their stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivatives thereof, are prepared and disclosed as antibacterial agents. Thus, e.g., II was prepared by a multistep procedure (preparation given). I were evaluated in S. aureus (ATCC 29213) antibacterial activity assays, e.g., II demonstrated a <4 μg/mL min. inhibitory concentration in LB media. The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).Product Details of 97859-49-9

The Article related to heterocyclic preparation antibacterial agent, pyridooxazinone preparation antibacterial agent, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.Product Details of 97859-49-9

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On February 27, 2014, Lv, Binhua; Li, Chengwei; Cao, Benwen published a patent.Electric Literature of 97859-49-9 The title of the patent was Preparation of substituted oxazolidinone compounds as factor Xα inhibitors. And the patent contained the following:

The present invention relates to substituted oxazolidinone compounds I [wherein R1 = 5-(un)substituted 2-thienyl or 4-(un)substituted Ph; R2 = 3-oxo-4-morpholinyl, 2-oxo-1-piperidinyl, etc.; R3 and R4 = independently H, D, F, Cl, OH, CN, etc.; R5 and R6 = independently H, D, F, Cl, OH, etc.; with proviso], pharmaceutically acceptable salts, crystal forms, hydrates, or solvates thereof as factor Xα inhibitors for treating and/or preventing thromboembolic diseases. For example, II was prepared in a multi-step synthesis, which showed inhibitory activity with IC50 of 0.002 nM against human blood-coagulation factor Xα. The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).Electric Literature of 97859-49-9

The Article related to preparation oxazolidinone factor xa inhibitor treatment thromboembolic disease human, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.Electric Literature of 97859-49-9

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem