On October 4, 2019, Peer Mohamed, Shahul Hameed; Bharatham, Nagakumar; Katagihallimath, Nainesh; Sharma, Sreevalli; Nandishaiah, Radha; Ramachandran, Vasanthi published a patent.Application of 97859-49-9 The title of the patent was Oxazolidinone compounds as antibiotics and process of preparation. And the patent contained the following:
The disclosure relates to compounds of formula I, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivative thereof and pharmaceutical compositions containing them as the active ingredient which can be used as medicaments. The aforementioned substances can also be used in the manufacture of medicaments for treatment, prevention, or suppression of diseases, and conditions mediated by microbes. The disclosure also relates to the synthesis and characterization of aforementioned substances. Compounds of formula I wherein A is absent and CH2; B is CH2 and CH2CH2; X1 is N and CR4; X2 is N and CR5; Y1 and Y2 are independently N and CR7; Z1 is O, S, NH and CH2; R1 is (un)substituted C1-6 alkyl, (un)substituted C2-6 alkenyl, (un)substituted C3-6 cycloalkyl, etc.; R2 is H, halo, OH, CN, C1-6 alkoxy, etc.; R3 is H, F, C1-4 alkoxy, etc.; R4 is H, C1-4 alkoxy, C1-6 haloalkyl, etc.; R5 is H, CN, (un)substituted C1-6 alkyl, CO2H, etc.; R6 is H, C1-6 alkyl and C1-6 alkoxy; R7 is H, halo, CN, C1-6 alkoxy, etc.; and stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivatives thereof, are claimed. Example compound II was prepared by reductive alkylation of 6-(5-(2-aminoethyl)-2-oxooxazolidin-3-yl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one with 2-(4-methyl-3,6-dioxo-4,6-dihydropyrido[2,3-b]pyrazin-5(3H)-yl)acetaldehyde. The invention compounds were evaluated for their antibacterial activity. From the assay, it was determined that compound II exhibited MIC values in the range of 0.06μg/mL to 0.5μg/mL. The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).Application of 97859-49-9
The Article related to oxazolidinone preparation antibiotic, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Application of 97859-49-9
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem