Quantitative determination of drugs in bulk and pharmaceutical dosage forms by using 2,3-dichloro-5,6-dicyanobenzoquinone was written by Srinivas, Bathini;Yadagiriswamy, P.;Venkateshwarlu, G.. And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2015.Application of 1665-48-1 This article mentions the following:
The present work narrates determination of drugs viz,. Metaxalone (MTX), Rasagiline (RSG), Aprepitant (APR) and Linezolid (LZD) based on formation of Charge Transfer Complex of drugs as n-electron donor with 2,3-dichloro-5,6-dicyanobenzoquinone(DDQ) as π-acceptor in bulk and pharmaceutical dosage forms. The selected drugs turned the yellow color solution of DDQ in Acetonitrile to thick brown color and exhibited a band at 585nm due to the formation of Complex of drugs with DDQ. Under the optimized exptl. conditions, Beer, s law is obeyed over the concentration ranges of 15-75 μg/mL, 10-50 μg/mL, 5-25 μg/mL and 10-50 μg/mL for, MTX, RSG, APR and LZD resp. The sensitivity, accuracy of methods, effect of reagent concentrations, polarity of solvents and effect of reaction time have been studied and optimized. The stoichiometric relationship was determined by Job’s continuous method and is found to be 1:1 in each case. These methods have been validated in terms of ICH guidelines and applied to the quantification of selected drugs in bulk and dosage forms. In the experiment, the researchers used many compounds, for example, 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one (cas: 1665-48-1Application of 1665-48-1).
5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one (cas: 1665-48-1) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. In another report, the incorporation of an additional substituted oxazolidine ring over a range of new biphenylazepinium salt organocatalysts for the asymmetric epoxidation of alkenes improved enantiocontrol over the parent structures.Application of 1665-48-1
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem