The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Oxazole( cas:288-42-6 ) is researched.COA of Formula: C3H3NO.Cao, Zhu; Zhang, Huihui; Wu, Xinxin; Li, Yahong; Zhu, Chen published the article 《Radical heteroarylation of unactivated remote C(sp3)-H bonds via intramolecular heteroaryl migration》 about this compound( cas:288-42-6 ) in Organic Chemistry Frontiers. Keywords: heteroarenyl alkanol regioselective radical heteroarylation; heteroaryl alkanone preparation. Let’s learn more about this compound (cas:288-42-6).
The radical-mediated heteroarylation of unactivated remote C(sp3)-H bonds via intramol. heteroaryl migration is achieved, leading to a variety of heteroaryl-substituted aliphatic ketones. A library of O-/S-/N-containing heteroaryls such as benzofuryl, benzothiazolyl, benzothienyl, benzoxazolyl, oxazolyl and thiazolyl are amenable to the migration approach. The heteroaryl migration was triggered by an azido radical-mediated hydrogen atom abstraction from unactivated aliphatic C(sp3)-H bonds. The transformation features mild C-C bond cleavage, good selectivity for tertiary C(sp3)-H bonds and broad functional group compatibility.
《Radical heteroarylation of unactivated remote C(sp3)-H bonds via intramolecular heteroaryl migration》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Oxazole)COA of Formula: C3H3NO.
Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem