With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.99395-88-7,(S)-4-Phenyloxazolidin-2-one,as a common compound, the synthetic route is as follows.
4-Pentenoic acid (compound X), 4-dimethylammoniumpyridine (DMAP) was added to a mixture of methylene dichloride and DMF at about 20C to about 30C and the reaction mass was cooled to about 15C to about 20C. Triethylamine and (S)-(+)-4-Phenyl-2-oxazolidinone (compound GammaChi’) was added to the reaction mass and the reaction mass was stirred for about 5-10 minutes. The reaction mass was then cooled to about 0C to about 5C. A solution of pivaloyl chloride in methylene dichloride was added to the reaction mass. The temperature of reaction mass was then raised to about 25C to about 30C and stirred for about 10-15 hours. After completion of reaction, the reaction mass was quenched in dilute sulfuric acid at about 0C to about 5C. The temperature of the reaction mass was raised to about 20C to about 30C and layers were separated. The aqueous layer was extracted with methylene dichloride. After washing with 5% potassium carbonate solution followed by brine, the organic layer was distilled off completely under reduced pressure to obtain oily residue. To this oily mass, cyclohexane was added at about 50C to about 55C and the reaction mass was cooled gradually to about 20C to about 30C and stirred for 2 hours, the reaction mass was filtered, the residue obtained was dried to get (4S)-3-(pent-4-enoyl)- 4-phenyl-l,3-oxazolidin-2-one (compound Vffl’) as off-white to pale yellow solid. HPLC Purity more than 98.0%., 99395-88-7
99395-88-7 (S)-4-Phenyloxazolidin-2-one 730424, aoxazolidine compound, is more and more widely used in various fields.
Reference£º
Patent; GLENMARK PHARMACEUTICALS LIMITED; NAIR, Ranjeet; BHIRUD, Shekhar Bhaskar; THANKI, Bhavin Prabhudas; BHISE, Sanjay Shashikant; KESHAV, Shrikant Prabhakar; JAGDHANE, Rajendra; CHAUDHARI, Ganesh Bhaskar; GAIKWAD, Nandkumar; GADGE, Sandip; (56 pag.)WO2019/87172; (2019); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem