With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95530-58-8,(R)-4-Isopropyloxazolidin-2-one,as a common compound, the synthetic route is as follows.
95530-58-8, To a cooled (-10 0C) solution of 8-(4-fluoro-3-methylphenyl)octanoic acid (0.486 g, 1.926 mmol) in 15 mL of THF, were added stepwise triethylamine (0.69 mL, 4.952 mmol) and pivaloyl chloride (0.23 mL, 1.889 mmol). The reaction mixture was stirred at -10 0C for 1 h and then LiCl (0.080 g, 1.889 mmol) and (R)-4-iso- propyloxazolidin-2-one (0.237 g, 1.834 mmol) were added stepwise. After being warmed slowly to room temperature and stirred for overnight, the reaction mixture was diluted with ethyl acetate (80 mL) and washed with saturated NaHCO3 solution and brine. The organic layer was dried (Na2SO4), filtered, and concentrated under reduced pressure. The product was isolated by Flash column chromatography(silica gel column) eluting with 0-100 % dichloromethane/hexanes to give the title compound as colorless oil (0.547 g, 82% yield). GC-MS: tR = 6.9 min; m/z 363 (M+).
95530-58-8 (R)-4-Isopropyloxazolidin-2-one 641505, aoxazolidine compound, is more and more widely used in various fields.
Reference£º
Patent; PANTHERA BIOPHARNA, LLC; WO2008/94592; (2008); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem