With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.875444-08-9,(4S,5R)-5-(3,5-Bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one,as a common compound, the synthetic route is as follows.
875444-08-9, To a solution of (4S,5R>5-[3,5-bis(trifluoromethyl) phenyl]-4-methyl-l,3-oxazolidin-2-one (0.050 g,0.16 mmol) in THF (1 ml) at 0C, NaH (7.6 mg, 0.19 mmol, 60%) was added. The mixture was stirred at0C for 30 min. The title compound from Step A (0.059 g, 0.21 mmol) was added. The whole mixturewas stirred at 0C for 1 h and warmed to room temperature for 4 h. The reaction was quenched withsaturated ammonium chloride. The organic was extracted with ethyl acetate (3 x 15 ml). The combinedethyl acetate layers were washed with brine and dried over sodium sulfate. The title compound wasobtained after preparative TLC purification using EtOAc:hexane = 2:8 as the elute. IH NMR (CDC13,500 MHz) 5 7.92 (s, IH), 7.82 (s, 2H), 7.55 (d, J = 8.5 Hz, IH), 7.43 (d, J = 2.5 Hz, IH), 7.23 (dd, J =8.5, 2.5 Hz, IH), 5.77 (d, / = 8.0 Hz, 1H),4.86 (d, J = 16.0 Hz, IH), 4.36 (d, J = 16.0 Hz, IH), 4.11 (m,ffl),0.82(d,J = 6.5Hz, 3H).
875444-08-9 (4S,5R)-5-(3,5-Bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one 23583229, aoxazolidine compound, is more and more widely used in various fields.
Reference£º
Patent; MERCK & CO., INC.; WO2006/14357; (2006); A1;,
Oxazolidine – Wikipedia
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