With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.497-25-6,Oxazolidin-2-one,as a common compound, the synthetic route is as follows.
General procedure: In a two-neck round-bottom flask equipped with a stir-bar, CuCl2 (0.2 equiv), oxazolidin-2-one (5.0 equiv), Na2CO3 or Cs2CO3 (2.0 equiv) and molecular sieve (4) were combined. The reaction flask was purged with oxygen for 15 min. A solution of pyridine (2.0 equiv) in dry toluene (0.2 M) was added to the reaction flask via a syringe at room temperature. Two balloons filled with oxygen were connected to the reaction flask via a needle. The flask was placed in an oil-bath and heated to 70 C. A solution of alkyne (1.0 equiv) in dry toluene was added over 4 h using a syringe pump. After the addition was completed, the reaction mixture was stirred at 70 C for 8 h and then cooled to room temperature. The crude mixture was concentrated under vacuum and the residue was purified by flash chromatography on silica gel., 497-25-6
The synthetic route of 497-25-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Lingua, Hugo; Vibert, Francois; Mouysset, Dominique; Siri, Didier; Bertrand, Michele P.; Feray, Laurence; Tetrahedron; vol. 73; 25; (2017); p. 3415 – 3422;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem