452339-73-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.452339-73-0,(R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one,as a common compound, the synthetic route is as follows.
In a 50 mL three-necked flask, Replace the nitrogen three times, 0 C, To a solution of compound l-16 (70 mg, 0.28 mmol) Of N, N-dimethylformamide (1 OmL) (3lmg, 0.28mmo 1) was added to the solution, and after the reaction was carried out at room temperature for 0.5 h, Compound 4_4 (100 mg, 0.31 mmol) was added to the reaction system, Continue to react for 3 h. Ethyl acetate (50 mL) was added, Followed by extraction with water (50 mL) and saturated brine (50 mL). Organic phase dry, filter, concentrate. Silica gel plate (ethyl acetate / petroleum ether = 1/4) was purified to give 13 mg of product as a pale yellow oil.
452339-73-0 (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one 10933894, aoxazolidine compound, is more and more widely used in various fields.
Reference£º
Patent; Yifang Bio-technology (Shanghai) Co., Ltd.; Dai Xing; Jiang Yueheng; Wang Yaolin; (21 pag.)CN107188813; (2017); A;,
Oxazolidine – Wikipedia
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