With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.139009-66-8,(S)-N-Boc-2,2-dimethyloxazolidine-4-carboxylic Acid,as a common compound, the synthetic route is as follows.
Step 3: Preparation of (S)-tert-butyl-4- (3 -(4-chlorobenzoyl)-4,5-dimethylthiophen-2- ylcarbamoyl)-2 ,2-dimethyloxazolidine-3 -carboxylate (Intermediate 44) To a solution of (S)-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine-4-carboxylic acid (Intermediate 4, 0.886 g, 3.61 mmol) in DCM (9 mL) was added Nmethylmorpholine (NMM) (0.397 mL, 3.61 mmol) followed by isobutyl chioroformate (0.474 mL, 3.61 mmol) at 0 C. The mixture was stirred for 30 mm at room temperature. After addition of (2-amino-4,5-dimethylthiophen-3 -yl)(4- chlorophenyl)methanone (Intermediate 43, 0.800 g, 3.01 mmol) to the mixture, thereaction mixture was stirred for 2 days at room temperature. The reaction mixture was diluted with DCM, washed with 2 N aq. HC1, saturated aq. NaHCO3 and water, dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by column chromatography on Si02 (Hex:EtOAc = 5:1 to 3:1 to 1:1) to obtain the title compound (1.80 g, 88%) as a viscous yellow oiL ?H-NMR (400 MHz, CDC13): (two sets from rotamers) 11.4 (brs, ill), 7.53 (d, J= 8.0 Hz, 2H), 7.41 (d, J= 8.4 Hz, 2H), 4.65-4.13 (m, 3H), 2.26 (s, 3H), 1.84 and 1.79 (s and s, 3H), 1.68 (s, 3H), 1.57 and 1.56 (s and s, 4H), 1.47 (s, 3H), 1.29- 1.24 (rn, 5H)., 139009-66-8
139009-66-8 (S)-N-Boc-2,2-dimethyloxazolidine-4-carboxylic Acid 6932187, aoxazolidine compound, is more and more widely used in various fields.
Reference£º
Patent; KAINOS MEDICINE, INC.; OH, Su-Sung; CHOI, Minjeong; WO2015/156601; (2015); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem