With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13590-42-6,(S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate,as a common compound, the synthetic route is as follows.
3 g (12 mmol) beta -benzyl-L-aspartate N-carboxyanhydride (BLA-NCA) was dissolved in 20 mL of DMF and (MW = 269.51 g / mol, 0.3 g, 1.2 mmol) in a 50 mL CH 2 Cl 2 mixture and polymerized at 40 C starting from the terminal primary amine group of the octadecylamine. The reaction mixture was stirred for 2 days. The reaction mixture was rotary evaporated under high vacuum to remove the CH2CI2. 20 mL of 0.1 N HCl was slowly added to precipitate the polymer, followed by centrifugation (3000 rpm) for 5 minutes. The supernatant was discarded and the remaining residue was lyophilized to remove residual water. PH-sensitive octadecylamine-p (API-Asp) 10 was synthesized by aminolysis of the octadecylamine-PBLA octadecylamine-PBLA using 1- (3-aminopropyl) imidazole. Octadecylamine-p (API-Asp) 10 (0.2, 74.8 mumol) was dissolved in 5 mL of DMSO, and after reaction and API (1 g, 7.9 mmol) in 25 under nitrogen it was stirred for 12 hours. The reaction mixture was added dropwise to 20 mL of 1 N cold HCl aqueous solution and dialyzed against 0.01 N HCl solution three times (Spectra / Por; MWCO: 1,000 Da). The final solution was lyophilized to give octadecylamine-p (API-Asp) 10 as a white solid was obtained.
13590-42-6, 13590-42-6 (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate 11736783, aoxazolidine compound, is more and more widely used in various fields.
Reference£º
Patent; Seoul National University Industry-Academic Cooperation Foundation; National Cancer Centre Singapore PTE; Institute For Basic Science; Hyun, Taek Hwan; Huii, Kam Man; Lung, Dae Sun; Jia, Hong Ping; (32 pag.)KR2016/105146; (2016); A;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem