With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108149-63-9,(R)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate,as a common compound, the synthetic route is as follows.
NaH (265 mg, 6.63 mmol) was added to a yellow solution of (S)-1-Boc-2,2-dimethyl-4-hydroxymethyloxazolidine (AstaTech Inc., Bristol, Pa.) (1 g, 4.19 mmol) in THF (10 ml). Then the mixture was stirred for 15 min at ambient temperature. The Methyliodid (323 muL, 5.19 mmol) was added to the yellow suspension and the mixture was stirred for 2 h 30 at rt. Then water was added to quench the reaction. The solvent was removed. The residue was purified by flash chromatography (DCM/MeOH: 5%?10% MeOH) to give the title compound (1.013 g, 94%). ESI-MS: 246.1 [M+H]+ (LC-MS 1); 1H NMR (400 MHz,
108149-63-9, 108149-63-9 (R)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate 11053464, aoxazolidine compound, is more and more widely used in various.
Reference£º
Patent; NOVARTIS AG; CARAVATTI, Giorgio; FAIRHURST, Robin Alec; FURET, Pascal; STAUFFER, Frederic; SEILER, Frank Hans; MCCARTHY, Clive; RUEEGER, Heinrich; US2013/225574; (2013); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem