Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Application In Synthesis of (S)-5-(Chloromethyl)oxazolidin-2-one. Introducing a new discovery about 169048-83-3, Name is (S)-5-(Chloromethyl)oxazolidin-2-one
The development of 2-phenylbenzoxazoles as inhibitors of cholesteryl ester transfer protein (CETP) is described. Efforts focused on finding suitable replacements for the central piperidine with the aim of reducing hERG binding: a main liability of our benchmark benzoxazole (1a). Replacement of the piperidine with a cyclohexyl group successfully attenuated hERG binding, but was accompanied by reduced in vivo efficacy. The approach of substituting a piperidine moiety with an oxazolidinone also attenuated hERG binding. Further refinement of this latter scaffold via SAR at the pyridine terminus and methyl branching on the oxazolidinone led to compounds 7e and 7f, which raised HDLc by 33 and 27 mg/dl, respectively, in our transgenic mouse PD model and without the hERG liability of previous series.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Application In Synthesis of (S)-5-(Chloromethyl)oxazolidin-2-one, you can also check out more blogs about169048-83-3
Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H1405NO – PubChem