Chemistry is traditionally divided into organic and inorganic chemistry. Safety of Oxazolidin-2-one, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 497-25-6
In vitro antitumor evaluation of some new tetra substituted 1,2,4-triazines
A new series of tetra substituted 1,2,4-triazines (4, 5, 7 and 8) was synthesized via the reaction of 3,1-oxazolinone (1) with thiosemicarbazide to give 6-hydroxy-5-(p-hydroxybenzylidene)-3-phenyl-2-(amino) thioxo-1,2,4-triazine (3). Treatment of 1,2,4-triazine derivative 3 with carbon disulphide and p-chlorophenacyl bromide yielded the corresponding 1,2,4-triazine derivatives 4 and 7. Acetylation of tetra-substituted 1,2,4-tri-azines 4 and 7 with acetic anhydride gave tri acetyl and di acetyl derivatives 5 and 8. Compounds structure was confirmed by IR,1H,13C-NMR, MS, and elemental analysis. The cytotoxic activities of some synthesized, 1,2,4-triazines were evaluated on human hepatocellular carcinoma cells (HepG-2) and human colon carcinoma cells (HCT-116) using the MTT method. We found that, compounds 5 (IC50 = 3.60 mug/mL) and 8 (IC50 = 4.40 mug/mL) have better activity against HCT-116 cell line than the reference doxorubcin (IC50 = 5.30 mug/mL), while compound 7 has best activity against HepG-2 cell line.
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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H286NO – PubChem