Safety of 2,6-Dichloropurine. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about Development of synthesis of phosphatidylinositol 3-kinase inhibitor puquitinib mesylate. Author is Shen, Dadong; Zhu, Jinlin; Wu, Guofeng; Sheng, Li; Gao, Haoling; Wang, Pu.
Puquitinib mesylate is a novel phosphatidylinositol 3-kinases (PI3K) inhibitor, which has been shown to be effective in the treatment of cancer. A convenient protocol for the synthesis of the compound at kilogram scale is described, using 2, 6-dichloropurine as starting material through amino-protection, SN2 reaction with high regioselectivity, BuchwaldHartwig coupling reaction, amino-deprotection and salt-forming reaction. The process is easy to operate and provides an effective way at kilogram scale produce with 48% yield in total.
As far as I know, this compound(5451-40-1)Safety of 2,6-Dichloropurine can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem