95530-58-8, (R)-4-Isopropyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,95530-58-8
To a solution of (R) -4-isopropyloxazolidin-2-one (25.0g, 0.194mol, 1.0eq) in anhydrous THF (1150 mL) was added n-BuLi (85.0 mL, 0.213mol, 1.1eq) at -78 under N2and the mixture was stirred at the same temperature for 1 h, a large number of white solids formed. Then propionyl chloride (20.0 mL, 0.232mol, 1.2eq) was added at -78 and the mixture was stirred at the same temperature for 1 h. After the consumption of (S) -4-isopropyloxazolidin-2-one monitored by TLC, the solution was poured into saturated ammonium chloride solution (1.2 L) and the mixture was extracted with EA (700 mL, 350 mL ¡Á 2) . The organic extract was washed with 1.0 N NaOH solution (1.0 L) and brine (1.0 L) , dried over anhydrous sodium sulfate, filtered, concentrated in vacuo and purified by SiO2column chromatography (PE : EA = 10: 1) to give the title compound as a colorless oil (32.6 g, 90.8%) . ESI m/z: calcd for C9H17NO3[M+H]+: 186.1, found 186.1.1H NMR (400 MHz, CDCl3) delta 4.48 -4.37 (m, 1H) , 4.27 (t, J = 8.7 Hz, 1H) , 4.21 (dd, J = 9.1, 3.1 Hz, 1H) , 3.04 -2.82 (m, 2H) , 2.45 -2.30 (m, 1H) , 1.17 (t, J = 7.4 Hz, 3H) , 0.90 (dd, J = 17.1, 7.0 Hz, 6H) .
95530-58-8 (R)-4-Isopropyloxazolidin-2-one 641505, aoxazolidine compound, is more and more widely used in various fields.
Reference£º
Patent; HANGZHOU DAC BIOTECH CO. LTD; ZHAO, Robert Yongxin; YANG, Qingliang; HUANG, Yuanyuan; ZHAO, Linyao; GAI, Shun; YE, Hangbo; LEI, Jun; XU, Yifang; CAO, Mingjun; GUO, Huihui; JIA, Junxiang; TONG, Qianqian; LI, Wenjun; ZHOU, Xiaomai; XIE, Hongsheng; BAI, Lu; CAI, Xiang; ZHUO, Xiaotao; ZHANG, Xiuzheng; ZHENG, Jun; (424 pag.)WO2019/127607; (2019); A1;,
Oxazolidine – Wikipedia
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