90719-32-7, (S)-4-Benzyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
90719-32-7, [00177] Results: Synthesis of the propionyl oxazolidinone 4 was accomplished without the requirement of a highly reactive base (Ho, G-J et al. J. Org. Chem. 60, 2271-2273 (1995)) and subsequent stereoselective aldol reaction with methacrolein (Nielsen, P. E. Chem. Biodivers. 7, 786-804 (2010)) was achieved under reaction conditions that do not require pre-generation of a metal enolate (Evans, D. A et al. J. Am. Chem. Soc. 124, 392-393 (2002)). Isolated by simple extraction, the TMS-ether 7 was converted to the stereodefmed allylic chloride 8 by Nb-mediated stereoselective halogenation (E:Z > 20: 1) (Ravikumar, P. C. et al. J. Org. Chem. 74, 7294-7299 (2009)). While seemingly difficult to accomplish in a highly selective fashion, hydrolysis of the imide proceeded uneventfully (without significant hydrolysis of the allylic chloride) and delivered 1 in >95% ee and 41% overall yield. Notably, this synthesis procedure delivers optically active 1 in acceptable yield and purity through a four-step sequence that does not require a single chromatographic operation. As an indication of the robust nature of this sequence, lOg of 4 was converted to ca. 4g of 1 routinely.
90719-32-7 (S)-4-Benzyloxazolidin-2-one 736225, aoxazolidine compound, is more and more widely used in various fields.
Reference£º
Patent; THE SCRIPPS RESEARCH INSTITUTE; MICALIZIO, Glenn, C.; KODADEK, Thomas; SARKAR, Mohosin; WO2013/36753; (2013); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem