7517-99-9, 5-(Hydroxymethyl)oxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
7517-99-9, To a stirred solution of TBDMS-C1 (5.74 g, 0.0384 mol), imidazole (3.4 g, 0.0512 mol), DMAP (0.31 g, 0.0025 mol) in DMF (15 mL), cooled to 0C, 5- (hydroxymethyl)oxazolidin-2-one (3 g, 0.0256 mmol) in DMF (15 mL) was added and stirred at 25 C for 2 h. After completion of the reaction, reaction mixture was quenched with water and extracted with ethyl acetate (3x 150ml). The separated organic layer was washed with water, brine, dried over Na2S04, filtered and concentrated under reduced pressure. It was purified by column chromatography on silica gel (230-400 mesh, 20-25% ethyl acetate in pet ether) to obtain lla (3.6 g, 61%); LC-MS Calculated for CioH2iNO3Si, 231.37, Observed 232.1. 1H 1H NMR (400 MHz, CDCl3): ?5.11 (s, 1H), 4.72-4.66 (m, 1H), 3.86-3.82 (m, 1H), 3.79-3.76 (m, 1H), 3.66-3.62 (m, 1H), 3.58-3.55 (m, 1H), 0.91 (s, 9H), 0.11 (s, 6H).
7517-99-9 5-(Hydroxymethyl)oxazolidin-2-one 10290773, aoxazolidine compound, is more and more widely used in various fields.
Reference£º
Patent; BUGWORKS RESEARCH INDIA PVT LTD; PEER MOHAMED, Shahul Hameed; BHARATHAM, Nagakumar; KATAGIHALLIMATH, Nainesh; SHARMA, Sreevalli; NANDISHAIAH, Radha; RAMACHANDRAN, Vasanthi; VENKATARAMAN, Balasubramanian; (221 pag.)WO2018/225097; (2018); A1;,
Oxazolidine – Wikipedia
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