497-25-6, Oxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
2-oxazolidinone (2 g, 23mmol) was dissolved in 15 mL of dry DMF at 0 C with 1.3 eq. of NaH (28 mmol, 1.15 g). The solution was stirred during 1 h, then 1.5 eq. (32 mmol, 3.68 mL) of propargyl bromide diluted in 7 mL of DMF was dropwised during 40 min at 0 C. After additional 20 min, the reaction was quenched with 1 mL of water, and the solvent removed in vacuo. After work-up (CHCl3/H2O; 30/10; V/V) and purification by chromatography (elution gradient: EP/AcOEt; 8/2 to 4/6; V/V), compound 3 (amber oil) was obtained in quantitative yield. Rf = 0.86 (CHCl3/EtOH; 7/3; V/V). FTMS-ESI calcd for C6H7O2NNa, MNa+ 148.0369, found 148.0363; 1H NMR (DMSO-d6): Oxazolidinone: 4.30 (t, 2H, J = 8.1 Hz, CH2-O), 3.56 (t, 2H, J = 8.1 Hz, CH2-N); Propargyl: 4.00 (d, 2H, J = 2.5 Hz, CH2), 3.32 (t, 1H, J = 2.5 Hz, CH). 13C NMR (DMSO-d6): Oxazolidinone: 157.5 (C=O), 75.4 (CH2-O), 61.9 (CH2-N); Propargyl: 79.9 (C-CH2), 78.1 (C-H), 43.5 (CH2)., 497-25-6
The synthetic route of 497-25-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Vergnaud, Julien; Faugeras, Pierre-Antoine; Chaleix, Vincent; Champavier, Yves; Zerrouki, Rachida; Tetrahedron Letters; vol. 52; 46; (2011); p. 6185 – 6189;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem