452339-73-0,452339-73-0, (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of (5R)-5- (2, 2-DIMETHYL-4H-1, 3-BENZODIOXIN-6-YL)-1, 3-OXAZOLIDIN-2-ONE (WO 0266422) (2. 00g) in DMF (25ML) under nitrogen was added sodium hydride (60% dispersion in mineral oil, 0. 38g) and the mixture was stirred at room temperature for 15 min. A solution of 4-[(6-BROMOHEXYL) OXY]-1-BUTENE (2. 07G) in DMF (5ml) was added dropwise and the mixture stirred for 3h. The reaction was quenched with water and partitioned between water and EtOAc. The organic phase was washed with brine, dried (MGS04), and evaporated to dryness. The residual oil was purified on a silica SPE bond elut cartridge (50G) using a gradient of 10%-30% EtOAc in cyclohexane (GRADMASTETM). The appropriate fractions were evaporated to give the title compound (2.66g) LCMS RT = 3.47 min.
452339-73-0 (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one 10933894, aoxazolidine compound, is more and more widely used in various fields.
Reference£º
Patent; GLAXO WELLCOME HOUSE; WO2004/37773; (2004); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem