184363-66-4, (S)-4-Phenyl-3-propionyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Weigh 2.2 g (10 mmol) of oxazolone ester (Formula VIII, R1 = phenyl, R2 = R3 = hydrogen) with a magnetic stirrer,The thermometer and the dropping funnel were dissolved in 20 ml of dichloromethane and cooled to -10 C.1.7 g (10 mmol) of titanium tetrachloride was added in that order, and 2.6 ml of diisopropylethylamine (20 mmol) was added thereto, and the mixture was kept for 1 hour.2.1 g (10 mmol) of the compound of formula III was dissolved in 10 ml of dichloromethane.This solution was slowly added dropwise to the solution of oxazolone and further stirred at the same temperature for 30 minutes.The reaction was quenched by the addition of 10% aqueous citric acid.The mixture was stood still, the aqueous layer was extracted with 30 ml of dichloromethane, and the organic phase was washed with 30 ml of water.Dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure.40 ml of methyl tert-butyl ether was added to the residue, and the suspension thus obtained was stirred at 20 to 25 C for 10 minutes, and then the product was isolated by filtration.Drying under reduced pressure gave a pale yellow crystalline compound (IV, R1 = phenyl, R2 = R3 = hydrogen). Yield: 2.72 g (63%) Purity: 98.3%, 184363-66-4
184363-66-4 (S)-4-Phenyl-3-propionyloxazolidin-2-one 226270, aoxazolidine compound, is more and more widely used in various fields.
Reference£º
Patent; Ningbo Ainuo Pharmaceutical Technology Co., Ltd.; Zhang Xini; Zhou Tao; Xiong Zhigang; Zhou Hao; Hu Tao; (9 pag.)CN108238981; (2018); A;,
Oxazolidine – Wikipedia
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