17016-83-0, (S)-4-Isopropyl-2-oxazolidinone is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: Butyllithium (2.5 M in hexane, 15.6 mL, 39.1 mmol, 1.01 equiv) was added dropwise to a solution of (S)-(+)-4-isopropyl-1,3-oxazolidin-2-one2 (5.00 g, 38.7 mmol) in anhydrous THF (70.0 mL) at -78 C under argon. The resulting mixture was stirred for 15 min and a freshly distilled 2-methyl-2E-pentenoyl chloride (5.13 g, 38.7 mmol) in dry THF (30 mL) was added via syringe at -78 C. The reaction was stirred for an additional 45 min at -78 C and then warmed to ambient temperature. Saturated aqueous ammonium chloride (50 mL) was added and the resulting mixture stirred for 30 min. The solvent was removed under reduced pressure and the remaining aqueous phase transferred to a separation funnel. The aqueous phase was extracted with DCM (2¡Á100 mL), the combined organics were washed with 3.0 M NaOH (25 mL), water (25 mL), brine (25 mL), dried over anhydrous sodium sulfate, filtered and evaporated under reduced pressure. The crude product was purified with flash chromatography using hexanes/ethyl acetate 0-20% as a gradient to give 96% (8.37 g) of A as a white solid., 17016-83-0
17016-83-0 (S)-4-Isopropyl-2-oxazolidinone 7157133, aoxazolidine compound, is more and more widely used in various fields.
Reference£º
Article; Banasik, Brent A.; Wang, Lee; Kanner, Arielle; Mikael Bergdahl; Tetrahedron; vol. 72; 19; (2016); p. 2481 – 2490;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem