The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one( cas:1194-22-5 ) is researched.Formula: C5H6N2O2.Prasanthkumar, Kavanal P.; Mohan, Hari; Pramod, Gopinathan; Suresh, Cherumuttathu H.; Aravindakumar, Charuvila T. published the article 《Anomalous reaction of oxide radical ion with 5-azacytosines: An experimental and theoretical study》 about this compound( cas:1194-22-5 ) in Chemical Physics Letters. Keywords: anomalous reaction oxide radical ion azacytosine pulse radiolysis. Let’s learn more about this compound (cas:1194-22-5).
The reactions of oxide radical ion (·O-) with 5-azacytosine (5AC) and 5-azacytidine (5ACyd) in aqueous medium were studied using the pulse radiolysis technique and quantum chem. calculation using d. functional theory (DFT). It is demonstrated that the major reaction pathway is the addition of ·O- to the ring nitrogen of 5AC, followed by a fast protonation of adducts by water. Only a minor percentage (<18%) undergoes an electron transfer reaction. The similarity in the reaction mechanism of ·O- (addition to azacytosine) and ·OH (which generally participates in an addition reaction) is an interesting observation and is quite unusual in the case of heterocyclic compounds Compound(1194-22-5)Formula: C5H6N2O2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one), if you are interested, you can check out my other related articles.
Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem